HHS Public Access Author manuscript Author Manuscript
Neurogastroenterol Motil. Author manuscript; available in PMC 2017 October 01. Published in final edited form as: Neurogastroenterol Motil. 2016 October ; 28(10): 1508–1517. doi:10.1111/nmo.12848.
The Impact of Abuse and Mood on Bowel Symptoms and HealthRelated Quality of Life in Irritable Bowel Syndrome (IBS) Navya Kanuri, M.D.1, Benjamin Cassell, M.D.1, Steven E. Bruce, Ph.D.4, Kamila S. White, Ph.D.4, Britt M. Gott, M.S.2, C. Prakash Gyawali, M.D., M.R.C.P.1, and Gregory S. Sayuk, M.D., M.P.H.1,2,3 1Division
of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri,
Author Manuscript
USA 2Department
of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA
3Gastroenterology
Section, John Cochran Veterans Affairs Medical Center, University of MissouriSt. Louis, Missouri, USA 4Center
for Trauma Recovery, University of Missouri-St. Louis, Missouri, USA
Abstract
Author Manuscript
Background—Irritable bowel syndrome (IBS) is a common abdominal pain disorder without an organic explanation. Abuse histories (physical, sexual, emotional) are prevalent in IBS. While abuse relates to mood disorders (depression and anxiety) also common in IBS, the influence of abuse on GI symptoms and health-related quality of life (HRQOL) and its independence from psychological symptom comorbidity, has not been studied. Methods—Consecutive GI outpatients completed the ROME III Research Diagnostic Questionnaire and questionnaires on trauma (Life-Stress Questionnaire), mood (Beck Depression/ Anxiety Inventories), somatic symptoms (PHQ-12) and HRQOL (SF-36). Current GI symptom Severity and Bother were assessed using 10-cm VAS scales.
Author Manuscript
Key Results—272 ROME-defined IBS (47.6±0.9 yrs, 81% female) and 246 non-FGID (51.6±1.0 yrs, 65% female) subjects participated. IBS patients reported greater rates of physical, sexual, and emotional abuse (p < 0.006 each), and higher depression, anxiety, and somatic symptoms (p < 0.001). Greater bowel symptom bother (7.4±0.2 vs 6.7±0.2, p=0.040), severity (7.7±0.2 vs 6.5±0.2, p
Neurogastroenterol Motil. Author manuscript; available in PMC 2017 October 01. Published in final edited form as: Neurogastroenterol Motil. 2016 October ; 28(10): 1508–1517. doi:10.1111/nmo.12848.
The Impact of Abuse and Mood on Bowel Symptoms and HealthRelated Quality of Life in Irritable Bowel Syndrome (IBS) Navya Kanuri, M.D.1, Benjamin Cassell, M.D.1, Steven E. Bruce, Ph.D.4, Kamila S. White, Ph.D.4, Britt M. Gott, M.S.2, C. Prakash Gyawali, M.D., M.R.C.P.1, and Gregory S. Sayuk, M.D., M.P.H.1,2,3 1Division
of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri,
Author Manuscript
USA 2Department
of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA
3Gastroenterology
Section, John Cochran Veterans Affairs Medical Center, University of MissouriSt. Louis, Missouri, USA 4Center
for Trauma Recovery, University of Missouri-St. Louis, Missouri, USA
Abstract
Author Manuscript
Background—Irritable bowel syndrome (IBS) is a common abdominal pain disorder without an organic explanation. Abuse histories (physical, sexual, emotional) are prevalent in IBS. While abuse relates to mood disorders (depression and anxiety) also common in IBS, the influence of abuse on GI symptoms and health-related quality of life (HRQOL) and its independence from psychological symptom comorbidity, has not been studied. Methods—Consecutive GI outpatients completed the ROME III Research Diagnostic Questionnaire and questionnaires on trauma (Life-Stress Questionnaire), mood (Beck Depression/ Anxiety Inventories), somatic symptoms (PHQ-12) and HRQOL (SF-36). Current GI symptom Severity and Bother were assessed using 10-cm VAS scales.
Author Manuscript
Key Results—272 ROME-defined IBS (47.6±0.9 yrs, 81% female) and 246 non-FGID (51.6±1.0 yrs, 65% female) subjects participated. IBS patients reported greater rates of physical, sexual, and emotional abuse (p < 0.006 each), and higher depression, anxiety, and somatic symptoms (p < 0.001). Greater bowel symptom bother (7.4±0.2 vs 6.7±0.2, p=0.040), severity (7.7±0.2 vs 6.5±0.2, p
