J Gynecol Oncol. 2016 Mar;27(2):e19 http://doi.org/10.3802/jgo.2016.27.e19 pISSN 2005-0380 · eISSN 2005-0399
Original Article
The impact of combined radiation and chemotherapy on outcome in uterine papillary serous carcinoma compared to chemotherapy alone Haider Mahdi, Benjamin Nutter, Fadi Abdul-Karim, Sudha Amarnath, Peter G Rose 1
Gynecologic Oncology Division, Ob/Gyn and Women’s Health Institute, Cleveland Clinic, Cleveland, OH, USA 2 Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA 3 Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA 4 Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA
Received: Jul 9, 2015 Revised: Jul 22, 2015 Accepted: Jul 29, 2015 Correspondence to Haider Mahdi Gynecologic Oncology Division, Ob/Gyn and Women’s Health Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA. E-mail: [email protected] Copyright © 2016. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ORCID Haider Mahdi http://orcid.org/0000-0002-6343-5314 Conflict of Interest No potential conflict of interest relevant to this article was reported.
ABSTRACT Objective: To investigate the impact of pelvic radiation on survival in patients with uterine serous carcinoma (USC) who received adjuvant chemotherapy. Methods: Patients with stage I-IV USC were identified from the Surveillance, Epidemiology, and End Results program 2000 to 2009. Patients were included if treated with surgery and chemotherapy. Patients were divided into two groups: those who received chemotherapy and pelvic radiation therapy (CT_RT) and those who received chemotherapy only (CT). KaplanMeier curves and Cox regression proportional hazard models were used. Results: Of the 1,838 included patients, 1,272 (69%) were CT and 566 (31%) were CT_ RT. Adjuvant radiation was associated with significant improvement in overall survival (OS; p
Original Article
The impact of combined radiation and chemotherapy on outcome in uterine papillary serous carcinoma compared to chemotherapy alone Haider Mahdi, Benjamin Nutter, Fadi Abdul-Karim, Sudha Amarnath, Peter G Rose 1
Gynecologic Oncology Division, Ob/Gyn and Women’s Health Institute, Cleveland Clinic, Cleveland, OH, USA 2 Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA 3 Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA 4 Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA
Received: Jul 9, 2015 Revised: Jul 22, 2015 Accepted: Jul 29, 2015 Correspondence to Haider Mahdi Gynecologic Oncology Division, Ob/Gyn and Women’s Health Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA. E-mail: [email protected] Copyright © 2016. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ORCID Haider Mahdi http://orcid.org/0000-0002-6343-5314 Conflict of Interest No potential conflict of interest relevant to this article was reported.
ABSTRACT Objective: To investigate the impact of pelvic radiation on survival in patients with uterine serous carcinoma (USC) who received adjuvant chemotherapy. Methods: Patients with stage I-IV USC were identified from the Surveillance, Epidemiology, and End Results program 2000 to 2009. Patients were included if treated with surgery and chemotherapy. Patients were divided into two groups: those who received chemotherapy and pelvic radiation therapy (CT_RT) and those who received chemotherapy only (CT). KaplanMeier curves and Cox regression proportional hazard models were used. Results: Of the 1,838 included patients, 1,272 (69%) were CT and 566 (31%) were CT_ RT. Adjuvant radiation was associated with significant improvement in overall survival (OS; p
