Exp. Path. Bd. 10, S. 289-293 (1975) Department of General and Experimental Pathology, Medical Academy, I,6dz (Poland )
The influence of polymorphonuclear leukocytes and macrophages on the growth of lym.phocytes and fibrohlasts in vitro By H.
TCHORZE\\,SKI.
A. D E:\YS and S. LIPINSKI
With one fif"nre (Receivl'd September 19, 19i.f) Küy words: polymorphonudear growth
leuko("~otes;
macrophages; lysosomes; Iymphocyte and fibroblast
Summary The inflllence of polymorphonllclear leukocytes (PMNL) and macrophage plasma, nllclei and Iysosome l'xtracts have been tested on Iymphocytes and fibroblasts growth in vitro. The stimulatory activity of P:\IXL lysosomes has been shown on lymphocyte and fibroblast growth. The macrophage IYHoSOml'S have shown a similar but lower activity. The role of lysosomes has been suggested in reparation and wound healing processes, presumably in inflammatory cell infiltrated regions.
It ha~ been suggested for many years that inflammatory cells prob abI)" PMNL and l1l-61. SELYE, H. J., A. CUNNINGHA]VI, A. SOMOGYl ami G. COTE, Al'l'eleration and inhibition of wounel healing by topical treatment with different types of inflammatory irritants. Am. J. Surg. 103,
1. ALEX.\NDEH, J. W., J. E. 2.
a. 4.
5. 6. 7.
8. 9.
10. 11. 19 13. 14.
167-175 (1969). 15. TCH6RZEWSKI, H., The role of lysosomes in lymphocyte transformation in vitro. Arch. Immuno!. Therap. Experiment. 20, 831-835 (1972).
292
16. -
Z. SULOWSKA ami A. DENYS, A new lymphoeyte transforming faetor derived from the lysosomes of polymorphonudear leucoeytes. Experientia 29, 481-483 (1973). 17. - R. FIDELRKI, A. DENYS, Z. SULOWSKA and T. PLUSA, Studies on the immunolo~iral properties of polymorphonuclear (PMN) leueoeytes. 11. Stimulation of lymphoeyte transformaticn by protein factor from P:VIN leueocytes. Ann. Immuno!. S, 29-35 (1973). 18. YARON, M., and W. CASTOR, Leukoeyte-ronnective tissne rell interadion. 1. Stimulation oi hyaluronate synthesis by live and !lead lUlkocytfs. Arthritis Rheum. 12, 365-373 (1969). Authors' address: Dr. hab. H. TCHORZEWSKI, Department oi General Pathology, Acad€my of l\fedicine, 90-647 LUdi, WAM Poland.
293
The influence of polymorphonuclear leukocytes and macrophages on the growth of lym.phocytes and fibrohlasts in vitro By H.
TCHORZE\\,SKI.
A. D E:\YS and S. LIPINSKI
With one fif"nre (Receivl'd September 19, 19i.f) Küy words: polymorphonudear growth
leuko("~otes;
macrophages; lysosomes; Iymphocyte and fibroblast
Summary The inflllence of polymorphonllclear leukocytes (PMNL) and macrophage plasma, nllclei and Iysosome l'xtracts have been tested on Iymphocytes and fibroblasts growth in vitro. The stimulatory activity of P:\IXL lysosomes has been shown on lymphocyte and fibroblast growth. The macrophage IYHoSOml'S have shown a similar but lower activity. The role of lysosomes has been suggested in reparation and wound healing processes, presumably in inflammatory cell infiltrated regions.
It ha~ been suggested for many years that inflammatory cells prob abI)" PMNL and l1l-61. SELYE, H. J., A. CUNNINGHA]VI, A. SOMOGYl ami G. COTE, Al'l'eleration and inhibition of wounel healing by topical treatment with different types of inflammatory irritants. Am. J. Surg. 103,
1. ALEX.\NDEH, J. W., J. E. 2.
a. 4.
5. 6. 7.
8. 9.
10. 11. 19 13. 14.
167-175 (1969). 15. TCH6RZEWSKI, H., The role of lysosomes in lymphocyte transformation in vitro. Arch. Immuno!. Therap. Experiment. 20, 831-835 (1972).
292
16. -
Z. SULOWSKA ami A. DENYS, A new lymphoeyte transforming faetor derived from the lysosomes of polymorphonudear leucoeytes. Experientia 29, 481-483 (1973). 17. - R. FIDELRKI, A. DENYS, Z. SULOWSKA and T. PLUSA, Studies on the immunolo~iral properties of polymorphonuclear (PMN) leueoeytes. 11. Stimulation of lymphoeyte transformaticn by protein factor from P:VIN leueocytes. Ann. Immuno!. S, 29-35 (1973). 18. YARON, M., and W. CASTOR, Leukoeyte-ronnective tissne rell interadion. 1. Stimulation oi hyaluronate synthesis by live and !lead lUlkocytfs. Arthritis Rheum. 12, 365-373 (1969). Authors' address: Dr. hab. H. TCHORZEWSKI, Department oi General Pathology, Acad€my of l\fedicine, 90-647 LUdi, WAM Poland.
293
