574 THE LEWIS SYSTEM: NEW HISTOCOMPATIBILITY ANTIGENS IN RENAL TRANSPLANTATION
R. ORIOL Institut
d’Immuno-Biologie, Hôpital Broussais
96 Rue Didot,
75674 Paris Cedex 14
J. CARTRON Centre National de Transfusion Sanguine, Hôpital Saint-Antoine, Paris
J. YVART Service de Transfusion Sanguine, Hôpital Saint-Joseph, Paris
Patients and Methods Patients.-255 first-kidney-transplant recipients were studied retrospectively. Transplantation had -been performed at 4 French centres and all the patients typed were included. Although the donors were not typed, transplants in Le and Se recipients should always be compatible for these systems, while transplants in lelle and se/se recipients are very likely to be incompatible because of the low frequency of lelle (0.1) and se/se (0.2) in the French population. Transplant-survival rates were calculated by the actuarial method.4 Saliva.-Samples were heated in a boiling water-bath for 10 min, centrifuged, and stored at —20°C. Saliva samples capable of inhibiting A, B, H, or Lewis agglutinin reactions were referred to as Se and Le, respectively, while saliva samples
A. DUBOUST
J. BEDROSSIAN
J. BARIETY Transplantation Unit, Hôpital Broussais, Paris J. C. GLUCKMAN Transplantation Unit, Hôpitaux Pitié-Salpétrière et Foch, Paris
M. F. GAGNADOUX
Transplantation Unit, Hôpital des Enfants-Malades, Paris Lewis antigen types (Le, le) were retrospectively determined in 255 first-kidneytransplant recipients. Actuarial survival of grafts at two years was significantly lower in the le/le recipients than in the Le recipients. This indicates that mismatching of these antigens contributes to rejection of kidney transplants. The effects of mismatching for the Lewis and HLA antigen systems seemed to be additive.
Summary
Fig. 2-Percentage actuarial survival of 255 renal transplants in‘ Le (.) and lelle (8) recipients as a function of time.
Introduction NATURAL Lewis antibodies
account
for half of all the
irregular erythrocyte antibodies detected. They can lyse red cells’ and may be lymphocytotoxic.2 The biosynthesis of A, B, H, and Lewis antigenic determinants is genetically controlled by four independent genes acting on the same molecule (fig. 1). Kidney transplants have much lower survival-rates in homozygous lelle recipients than in Lrecipients (P
R. ORIOL Institut
d’Immuno-Biologie, Hôpital Broussais
96 Rue Didot,
75674 Paris Cedex 14
J. CARTRON Centre National de Transfusion Sanguine, Hôpital Saint-Antoine, Paris
J. YVART Service de Transfusion Sanguine, Hôpital Saint-Joseph, Paris
Patients and Methods Patients.-255 first-kidney-transplant recipients were studied retrospectively. Transplantation had -been performed at 4 French centres and all the patients typed were included. Although the donors were not typed, transplants in Le and Se recipients should always be compatible for these systems, while transplants in lelle and se/se recipients are very likely to be incompatible because of the low frequency of lelle (0.1) and se/se (0.2) in the French population. Transplant-survival rates were calculated by the actuarial method.4 Saliva.-Samples were heated in a boiling water-bath for 10 min, centrifuged, and stored at —20°C. Saliva samples capable of inhibiting A, B, H, or Lewis agglutinin reactions were referred to as Se and Le, respectively, while saliva samples
A. DUBOUST
J. BEDROSSIAN
J. BARIETY Transplantation Unit, Hôpital Broussais, Paris J. C. GLUCKMAN Transplantation Unit, Hôpitaux Pitié-Salpétrière et Foch, Paris
M. F. GAGNADOUX
Transplantation Unit, Hôpital des Enfants-Malades, Paris Lewis antigen types (Le, le) were retrospectively determined in 255 first-kidneytransplant recipients. Actuarial survival of grafts at two years was significantly lower in the le/le recipients than in the Le recipients. This indicates that mismatching of these antigens contributes to rejection of kidney transplants. The effects of mismatching for the Lewis and HLA antigen systems seemed to be additive.
Summary
Fig. 2-Percentage actuarial survival of 255 renal transplants in‘ Le (.) and lelle (8) recipients as a function of time.
Introduction NATURAL Lewis antibodies
account
for half of all the
irregular erythrocyte antibodies detected. They can lyse red cells’ and may be lymphocytotoxic.2 The biosynthesis of A, B, H, and Lewis antigenic determinants is genetically controlled by four independent genes acting on the same molecule (fig. 1). Kidney transplants have much lower survival-rates in homozygous lelle recipients than in Lrecipients (P
