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Biochimica et Biophysica Acta, 474 ( 1977) 268--278 © Elsevier/North-Holland Biomedical Press

BBA 98815

THE MECHANISM OF INHIBITION OF B A C T E R I O P H A G E T7 R N A SYNTHESIS BY ACRIDINES, DIACRIDINES AND ACTINOMYCIN D

ANDREAS H. SARRIS, EDWARD G. NILES * and E.S. CANELLAKIS

Department of Pharmacology, Yale University, Medical School, New Haven, Conn. 06510 (U.S.A.) (Received May 10th, 1976)

Summary A homologous series of diacridines, as well as 9-amino acridine, were assayed for their ability to interfere with the synthesis of R N A (bands I--VI) by bacteriophage T7 DNA

The mechanism of inhibition of bacteriophage T7 RNA synthesis by acridines, diacridines and actinomycin D.

268 Biochimica et Biophysica Acta, 474 ( 1977) 268--278 © Elsevier/North-Holland Biomedical Press BBA 98815 THE MECHANISM OF INHIBITION OF B A C T...
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