Eur J Clin Pharmacol (1990) 39:311-313 EuropeanJournalof ( ~ ( ~ @ ~ © Springer-Verlag 1990

The onset of effect of the Hi-antagonist acrivastine ("Semprex") assessed by histamine bronchial challenge in volunteers R E. Rolan, S. Phillips, J. Adams and J. Posner Department of Clinical Pharmacology, Wellcome Research Laboratories, Beckenham, Kent, UK Received: November 30, 1989/Accepted in revised form: April 3, 1990

Summary. T h e o n s e t of effect of acrivastine, a n e w H i - a n tagonist, has b e e n assessed using a n t a g o n i s m of hist a m i n e - i n d u c e d b r o n c h o c o n s t r i c t i o n in sensitive v o l u n teers. A c r i v a s t i n e a d m i n i s t e r e d 30, 45, 60 o r 90 rain b e f o r e c h a l l e n g e p r o d u c e d a right-shift o f the h i s t a m i n e d o s e - r e s p o n s e c u r v e of at least 8-fold i n d i c a t i n g t h a t a clinically d e s i r e d d e g r e e of H i - a n t a g o n i s m was p r e s e n t within 30 m i n of i n g e s t i o n of t h e r e c o m m e n d e d t h e r a p e u t i c dose.

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