Author’s Accepted Manuscript The prevalence and predictors of bipolar and borderline personality disorders comorbidity: Systematic review and meta-analysis M. Fornaro, L. Orsolini, S. Marini, D. De Berardis, G. Perna, A. Valchera, L. Ganança, M. Solmi, N. Veronese, B. Stubbs www.elsevier.com/locate/jad
PII: DOI: Reference:
S0165-0327(15)31291-X http://dx.doi.org/10.1016/j.jad.2016.01.040 JAD8012
To appear in: Journal of Affective Disorders Received date: 18 November 2015 Revised date: 4 January 2016 Accepted date: 24 January 2016 Cite this article as: M. Fornaro, L. Orsolini, S. Marini, D. De Berardis, G. Perna, A. Valchera, L. Ganança, M. Solmi, N. Veronese and B. Stubbs, The prevalence and predictors of bipolar and borderline personality disorders comorbidity: Systematic review and meta-analysis, Journal of Affective Disorders, http://dx.doi.org/10.1016/j.jad.2016.01.040 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
The prevalence and predictors of Bipolar and Borderline Personality disorders comorbidity: systematic review and meta-analysis
Fornaro M. 1; Orsolini, L. 2,3,4; Marini S. 5; De Berardis D. 6; Perna G. 7; Valchera A.4; Ganança L.1,8; Solmi M.9,10; Veronese N11; Stubbs B 12,13
1. New York State Psychiatric Institute, Columbia University, NY, USA 2. School of Life and Medical Sciences, University of Hertfordshire, Hatfield, Herts, UK 3. Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands 4. Hermanas Hospitalarias – Villa San Giuseppe, Ascoli Piceno, Italy 5. Department of Neuroscience & Imaging, “G. D’Annunzio” University, Chieti, Italy 6. National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini”, ASL 4, Teramo, Italy 7. Hermanas Hospitalarias - Villa San Benedetto Menni Hospital, Department of Clinical Neurosciences, FoRiPsi 8. Department of Psychiatry, School of Medicine, University of Lisbon, Portugal 9. Department of Neuroscience, University of Padova, Padua, Italy 10. National Health Care System, Padua Local Unit ULSS 17, Italy 11. Department of Medicine- DIMED, Geriatrics Section, University of Padua, Italy 12. Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London SE5 8AZ, UK 13. Health Service and Population Research Department, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
Michele FORNARO, MD, PhD: [email protected] Laura ORSOLINI, MD: [email protected] Stefano MARINI, MD: [email protected] Domenico DE BERARDIS, MD, PhD: [email protected] Giampaolo PERNA, MD, PhD [email protected] Alessandro VALCHERA, MD [email protected] Licinia GANANÇA, MD [email protected] Marco SOLMI, MD [email protected] Nicola VERONESE, MD [email protected] Brendon STUBBS, MSc, PhD: [email protected]
Corresponding author: Michele Fornaro, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 42, room 2729, NYC, ZIP 10032. Tel. +1(646) 774-5000. Email: [email protected]
Abstract Introduction: Data about the prevalence of borderline personality (BPD) and bipolar (BD) disorders comorbidity are scarce and the boundaries remain controversial. We conducted a systematic review and meta-analysis investigating the prevalence of BPD in BD and BD in people with BPD.
Methods: Two independent authors searched MEDLINE, Embase, PsycINFO and the Cochrane Library from inception till November 4 2015. Articles reporting the prevalence of BPD and BD were included. A random effects meta-analysis and meta-regression were conducted. Results: Overall, 42 papers were included: 28 considering BPD in BD and 14 considering BD in BPD. The trim and fill adjusted analysis demonstrated the prevalence of BPD among 5,273 people with BD (39.94±11.78 years, 44% males) was 21.6% (95% CI 17.0-27.1). Higher comorbid BPD in BD were noted in BD II participants (37.7%, 95% CI 21.9-56.6, studies=6) and North American studies (26.2%, 95% CI 18.7-35.3, studies=11). Meta regression established that a higher percentage of males and higher mean age significantly (p
PII: DOI: Reference:
S0165-0327(15)31291-X http://dx.doi.org/10.1016/j.jad.2016.01.040 JAD8012
To appear in: Journal of Affective Disorders Received date: 18 November 2015 Revised date: 4 January 2016 Accepted date: 24 January 2016 Cite this article as: M. Fornaro, L. Orsolini, S. Marini, D. De Berardis, G. Perna, A. Valchera, L. Ganança, M. Solmi, N. Veronese and B. Stubbs, The prevalence and predictors of bipolar and borderline personality disorders comorbidity: Systematic review and meta-analysis, Journal of Affective Disorders, http://dx.doi.org/10.1016/j.jad.2016.01.040 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
The prevalence and predictors of Bipolar and Borderline Personality disorders comorbidity: systematic review and meta-analysis
Fornaro M. 1; Orsolini, L. 2,3,4; Marini S. 5; De Berardis D. 6; Perna G. 7; Valchera A.4; Ganança L.1,8; Solmi M.9,10; Veronese N11; Stubbs B 12,13
1. New York State Psychiatric Institute, Columbia University, NY, USA 2. School of Life and Medical Sciences, University of Hertfordshire, Hatfield, Herts, UK 3. Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands 4. Hermanas Hospitalarias – Villa San Giuseppe, Ascoli Piceno, Italy 5. Department of Neuroscience & Imaging, “G. D’Annunzio” University, Chieti, Italy 6. National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini”, ASL 4, Teramo, Italy 7. Hermanas Hospitalarias - Villa San Benedetto Menni Hospital, Department of Clinical Neurosciences, FoRiPsi 8. Department of Psychiatry, School of Medicine, University of Lisbon, Portugal 9. Department of Neuroscience, University of Padova, Padua, Italy 10. National Health Care System, Padua Local Unit ULSS 17, Italy 11. Department of Medicine- DIMED, Geriatrics Section, University of Padua, Italy 12. Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London SE5 8AZ, UK 13. Health Service and Population Research Department, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
Michele FORNARO, MD, PhD: [email protected] Laura ORSOLINI, MD: [email protected] Stefano MARINI, MD: [email protected] Domenico DE BERARDIS, MD, PhD: [email protected] Giampaolo PERNA, MD, PhD [email protected] Alessandro VALCHERA, MD [email protected] Licinia GANANÇA, MD [email protected] Marco SOLMI, MD [email protected] Nicola VERONESE, MD [email protected] Brendon STUBBS, MSc, PhD: [email protected]
Corresponding author: Michele Fornaro, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 42, room 2729, NYC, ZIP 10032. Tel. +1(646) 774-5000. Email: [email protected]
Abstract Introduction: Data about the prevalence of borderline personality (BPD) and bipolar (BD) disorders comorbidity are scarce and the boundaries remain controversial. We conducted a systematic review and meta-analysis investigating the prevalence of BPD in BD and BD in people with BPD.
Methods: Two independent authors searched MEDLINE, Embase, PsycINFO and the Cochrane Library from inception till November 4 2015. Articles reporting the prevalence of BPD and BD were included. A random effects meta-analysis and meta-regression were conducted. Results: Overall, 42 papers were included: 28 considering BPD in BD and 14 considering BD in BPD. The trim and fill adjusted analysis demonstrated the prevalence of BPD among 5,273 people with BD (39.94±11.78 years, 44% males) was 21.6% (95% CI 17.0-27.1). Higher comorbid BPD in BD were noted in BD II participants (37.7%, 95% CI 21.9-56.6, studies=6) and North American studies (26.2%, 95% CI 18.7-35.3, studies=11). Meta regression established that a higher percentage of males and higher mean age significantly (p
