Heart & Lung 43 (2014) 569e573
Contents lists available at ScienceDirect
Heart & Lung journal homepage: www.heartandlung.org
Thrombocytopenia is an independent predictor of mortality in pulmonary hypertension Mohammad Khalid Mojadidi, MD *, David Goodman-Meza, MD, Parham Eshtehardi, MD, FAHA, Mohan Pamerla, MD, Pavlos Msaouel, MD, PhD, Scott C. Roberts, MD, Jared S. Winoker, MD, Neville M. Jadeja, MD, Ronald Zolty, MD Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center and Jacobi Medical Center, Bronx, NY, USA
a r t i c l e i n f o
a b s t r a c t
Article history: Received 25 April 2014 Received in revised form 21 July 2014 Accepted 23 July 2014 Available online 29 August 2014
Background: Established prognostic factors for pulmonary hypertension (PH) include brain natriuretic peptide, troponins and hemodynamic measures such as central venous pressure and cardiac output. The prognostic role of thrombocytopenia, however, has yet to be determined in patients with PH. The aim of this study was to evaluate effect of thrombocytopenia on mortality in patients with PH. Methods: 521 patients with severe PH, defined by a pulmonary artery systolic pressure >60 mm Hg on transthoracic echocardiography and a platelet count measured within one month after diagnosis were enrolled from three hospitals of Montefiore Medical Center. The cohort was divided into two groups: mild thrombocytopenia to a normal platelet count (platelet count 100,000e450,000 per uL); and moderate to severe thrombocytopenia (platelet count
Contents lists available at ScienceDirect
Heart & Lung journal homepage: www.heartandlung.org
Thrombocytopenia is an independent predictor of mortality in pulmonary hypertension Mohammad Khalid Mojadidi, MD *, David Goodman-Meza, MD, Parham Eshtehardi, MD, FAHA, Mohan Pamerla, MD, Pavlos Msaouel, MD, PhD, Scott C. Roberts, MD, Jared S. Winoker, MD, Neville M. Jadeja, MD, Ronald Zolty, MD Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center and Jacobi Medical Center, Bronx, NY, USA
a r t i c l e i n f o
a b s t r a c t
Article history: Received 25 April 2014 Received in revised form 21 July 2014 Accepted 23 July 2014 Available online 29 August 2014
Background: Established prognostic factors for pulmonary hypertension (PH) include brain natriuretic peptide, troponins and hemodynamic measures such as central venous pressure and cardiac output. The prognostic role of thrombocytopenia, however, has yet to be determined in patients with PH. The aim of this study was to evaluate effect of thrombocytopenia on mortality in patients with PH. Methods: 521 patients with severe PH, defined by a pulmonary artery systolic pressure >60 mm Hg on transthoracic echocardiography and a platelet count measured within one month after diagnosis were enrolled from three hospitals of Montefiore Medical Center. The cohort was divided into two groups: mild thrombocytopenia to a normal platelet count (platelet count 100,000e450,000 per uL); and moderate to severe thrombocytopenia (platelet count
