Endocrine Research
Time-Course of Prednisone Effects on Hormonal and Inflammatory Responses at Rest and During Resistance Exercise
Authors
K. Collomp1, 2, H. Zorgati1, F. Cottin1, M.-C. Do1, Z. Labsy1, O. Gagey1, F. Lasne2, F. Prieur1, R. Collomp3
Affiliations
1
Key words ▶ glucocorticoid ● ▶ resistance exercise ● ▶ kinetic ● ▶ DHEA-S ● ▶ aldosterone ● ▶ cytokines ●
Abstract
Bibliography DOI http://dx.doi.org/ 10.1055/s-0034-1395608 Published online: 2015 Horm Metab Res © Georg Thieme Verlag KG Stuttgart · New York ISSN 0018-5043 Correspondence K. Collomp Laboratoire CIAMS Université Paris Sud – Université Orléans 2 Allée du Château Université d’Orléans 45062 Orléans Cedex 2 France Tel.: + 33/2/38 417 178 Fax: + 33/2/38 417 260 [email protected]
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Glucocorticoids are among the most commonly used drugs. They are widely administered for acute and chronic musculoskeletal pain, as well as for several other pain syndromes, although their therapeutic use is sometimes diverted for doping purposes. Their time-course effects on hormonal and inflammatory responses nevertheless remain poorly understood, both at rest and during exercise. We therefore studied the alterations induced by 1 week of prednisone treatment (60 mg daily) in recreationally trained male athletes after 2 days (i. e., acute) and 7 days (i. e., short-term). Hormonal (i. e., DHEA, DHEA-S, aldosterone, and testosterone) and pro- and antiinflammatory markers (i. e., IL-6, IL-10, and IL-1β) were investigated at rest and after resistance exercise. A significant decrease in DHEA and DHEA-S (p 3 months), especially on the cardiovascular and metabolic systems and bone parameters, and these effects seem directly related to dosage, treatment duration, and the strength of the molecule and its administration route [1–5]. Numerous studies have also demonstrated that, after short-term GC intake, the hypothalamic-pituitary axis (HPA) is altered at rest through negative feedback, with marked decreases in cortisol and adrenocorticotropin hormone (ACTH) [6–10]. These works were extended to define the pattern
DHEA-S ratio, aldosterone, or testosterone was demonstrated after acute prednisone intake. A significant increment in IL-10 and a significant decrement in IL-6 (p
Time-Course of Prednisone Effects on Hormonal and Inflammatory Responses at Rest and During Resistance Exercise
Authors
K. Collomp1, 2, H. Zorgati1, F. Cottin1, M.-C. Do1, Z. Labsy1, O. Gagey1, F. Lasne2, F. Prieur1, R. Collomp3
Affiliations
1
Key words ▶ glucocorticoid ● ▶ resistance exercise ● ▶ kinetic ● ▶ DHEA-S ● ▶ aldosterone ● ▶ cytokines ●
Abstract
Bibliography DOI http://dx.doi.org/ 10.1055/s-0034-1395608 Published online: 2015 Horm Metab Res © Georg Thieme Verlag KG Stuttgart · New York ISSN 0018-5043 Correspondence K. Collomp Laboratoire CIAMS Université Paris Sud – Université Orléans 2 Allée du Château Université d’Orléans 45062 Orléans Cedex 2 France Tel.: + 33/2/38 417 178 Fax: + 33/2/38 417 260 [email protected]
▼
Glucocorticoids are among the most commonly used drugs. They are widely administered for acute and chronic musculoskeletal pain, as well as for several other pain syndromes, although their therapeutic use is sometimes diverted for doping purposes. Their time-course effects on hormonal and inflammatory responses nevertheless remain poorly understood, both at rest and during exercise. We therefore studied the alterations induced by 1 week of prednisone treatment (60 mg daily) in recreationally trained male athletes after 2 days (i. e., acute) and 7 days (i. e., short-term). Hormonal (i. e., DHEA, DHEA-S, aldosterone, and testosterone) and pro- and antiinflammatory markers (i. e., IL-6, IL-10, and IL-1β) were investigated at rest and after resistance exercise. A significant decrease in DHEA and DHEA-S (p 3 months), especially on the cardiovascular and metabolic systems and bone parameters, and these effects seem directly related to dosage, treatment duration, and the strength of the molecule and its administration route [1–5]. Numerous studies have also demonstrated that, after short-term GC intake, the hypothalamic-pituitary axis (HPA) is altered at rest through negative feedback, with marked decreases in cortisol and adrenocorticotropin hormone (ACTH) [6–10]. These works were extended to define the pattern
DHEA-S ratio, aldosterone, or testosterone was demonstrated after acute prednisone intake. A significant increment in IL-10 and a significant decrement in IL-6 (p
