TOPICAL MUSTINE HYDROCHLORIDE AND PSORIASIS: A FOLLOW-UP STUDY M. J . PURDY Haniitton,
Ncic
Zealand
SUMMARY
Thirtv-foiir patients xcith nriginatty extensive psunasis,Jor n'lioin topicat mustine treatment had heen instituted more than one year previoiisty, icere siiccessfiilty fottmced up. That the hii^h alter,i^v rate does not preclude the usefulness of this form of therapy in selected eases ts'u'ell shown. Seventv-one pereent had a good result and over 50 per cent needed ontv occasional applications for readv control and )isc mustine as their treatment of choice. ]'ortv-seveii percent developed aUeyi{v hut 6r'} per eejit of tJwse were desensitized.
INTRODUCTION
^["'I"
Tlie statemetil lias been made that " Despite a hiAl, allerj:;y rate, tc^pieal mustine liydrochloride i.s well worth a trial in cases of .stubl^orn psoriasis. Tlie development of allergy in such mittcnt
continued
use for recurrent
OJj>attcui:
''"^v.f,"',?
lesions "
"
(Purdy 197.3). 0{ the twenty-nine cases tlien studied only The purpose of tlie present study was to discover wliether a longer-term foUow-uii would support tlie contention. MKTIIOD The M patients were selected simply on the grounds that they liad lx-en introd\iced to
Dear
,
1 am carrying OHI a survey of the later results of Kindly complete this form by ticking the appropriate squares and reUnn H in the aceoinpanymK "':^''^"^^ ^^ appreciated,
Yours sincerely
(Dr. M. J. Purdy)
H p, ^, D
Musiine regularlv
D
Mtusthie occasionally | ] Other treatment r_i Commenis: Thus of tlie M patients witli severe p.soriasis introduced lo topical mustino hydroch]t)ride tliej-ajH' between one and tlirec years prior to this survey : Twenty-four (71 per cent) Iiave a good result ;
initiallv was as pre\iousU' stated (Purd^' 1973). The-following' .questionnaire was posted t!, the patients selected. Five failed to reply and 15 patients were able to attend in person":
No patches ^^ f^,,,. .^^^^^^^,^ .,, , , Many pal.hc.
o(casionan> , ^
^ }^J^^ ^ ^ ^ ^ ^'-''^^"l-^^ ^ ^^"'-^'•«'^'"t^^'^^" ' ^^^^ Ten («3 per cent of these sixteen) were .successfully desensitized and could revert to the treatment at normal strength ; IXxree (9 per cent)
deA'eloped resistance to
DISCUSSION 1- Mustine hydrochloride solution must be precisely prepared lieing a powerful vesicant in higher concentrations. The strength of 10 mg per 50 nil of water used therapeutically borders
JNo
Lie ucci q
iNo
1 ,,,,,. ^ L Micha.-lideb, P., and Prcslia, . \ . U. (H)72) ; ' ' - • nd Inlraveiioiis .Administration I'rcceding al I'sc in Patients with Psoriasis " , ,/. liivc.
Ncic
Zealand
SUMMARY
Thirtv-foiir patients xcith nriginatty extensive psunasis,Jor n'lioin topicat mustine treatment had heen instituted more than one year previoiisty, icere siiccessfiilty fottmced up. That the hii^h alter,i^v rate does not preclude the usefulness of this form of therapy in selected eases ts'u'ell shown. Seventv-one pereent had a good result and over 50 per cent needed ontv occasional applications for readv control and )isc mustine as their treatment of choice. ]'ortv-seveii percent developed aUeyi{v hut 6r'} per eejit of tJwse were desensitized.
INTRODUCTION
^["'I"
Tlie statemetil lias been made that " Despite a hiAl, allerj:;y rate, tc^pieal mustine liydrochloride i.s well worth a trial in cases of .stubl^orn psoriasis. Tlie development of allergy in such mittcnt
continued
use for recurrent
OJj>attcui:
''"^v.f,"',?
lesions "
"
(Purdy 197.3). 0{ the twenty-nine cases tlien studied only The purpose of tlie present study was to discover wliether a longer-term foUow-uii would support tlie contention. MKTIIOD The M patients were selected simply on the grounds that they liad lx-en introd\iced to
Dear
,
1 am carrying OHI a survey of the later results of Kindly complete this form by ticking the appropriate squares and reUnn H in the aceoinpanymK "':^''^"^^ ^^ appreciated,
Yours sincerely
(Dr. M. J. Purdy)
H p, ^, D
Musiine regularlv
D
Mtusthie occasionally | ] Other treatment r_i Commenis: Thus of tlie M patients witli severe p.soriasis introduced lo topical mustino hydroch]t)ride tliej-ajH' between one and tlirec years prior to this survey : Twenty-four (71 per cent) Iiave a good result ;
initiallv was as pre\iousU' stated (Purd^' 1973). The-following' .questionnaire was posted t!, the patients selected. Five failed to reply and 15 patients were able to attend in person":
No patches ^^ f^,,,. .^^^^^^^,^ .,, , , Many pal.hc.
o(casionan> , ^
^ }^J^^ ^ ^ ^ ^ ^'-''^^"l-^^ ^ ^^"'-^'•«'^'"t^^'^^" ' ^^^^ Ten («3 per cent of these sixteen) were .successfully desensitized and could revert to the treatment at normal strength ; IXxree (9 per cent)
deA'eloped resistance to
DISCUSSION 1- Mustine hydrochloride solution must be precisely prepared lieing a powerful vesicant in higher concentrations. The strength of 10 mg per 50 nil of water used therapeutically borders
JNo
Lie ucci q
iNo
1 ,,,,,. ^ L Micha.-lideb, P., and Prcslia, . \ . U. (H)72) ; ' ' - • nd Inlraveiioiis .Administration I'rcceding al I'sc in Patients with Psoriasis " , ,/. liivc.
