OPHTHALMIC IMAGES
Trans-Synaptic Degeneration of Lateral Geniculate Nuclei Following Remote Loss of Right Eye John P. Rossiter, MB, BCh, PhD A Autopsy specimen
B
Control
3
6 5
IL
4
2
3
2 1
C
Right lateral geniculate nucleus
D Left lateral geniculate nucleus
6
6 6 6 5
5 4
5
5
4
3 2
3
1
2 1
A, An autopsy of an adult patient who underwent remote enucleation revealed optic atrophy (arrowhead). Compared with control magnocellular and parvocellular layers (ie, layers 1, 2, and 3-6) (B), the patient’s lateral geniculate nuclei showed degeneration of layers 2, 3, and 5 on the right side (C) and of layers 1, 4, and 6 on the left side (D) (cresyl-violet, original magnification ×12 [insets: cresyl-violet, original magnification ×40]). IL indicates intercalated layer. ARTICLE INFORMATION Correction: This article was corrected on January 21, 2015, to fix an error in the figure. JAMA Ophthalmol. 2015;133(1):e141789. doi:10.1001/jamaophthalmol.2014.1789
jamaophthalmology.com Corrected on January 21, 2015
(Reprinted) JAMA Ophthalmology Published online January 8, 2015
Copyright 2015 American Medical Association. All rights reserved.
Downloaded From: http://archopht.jamanetwork.com/ by a Karolinska Institutet University Library User on 05/23/2015
1/1
Trans-Synaptic Degeneration of Lateral Geniculate Nuclei Following Remote Loss of Right Eye John P. Rossiter, MB, BCh, PhD A Autopsy specimen
B
Control
3
6 5
IL
4
2
3
2 1
C
Right lateral geniculate nucleus
D Left lateral geniculate nucleus
6
6 6 6 5
5 4
5
5
4
3 2
3
1
2 1
A, An autopsy of an adult patient who underwent remote enucleation revealed optic atrophy (arrowhead). Compared with control magnocellular and parvocellular layers (ie, layers 1, 2, and 3-6) (B), the patient’s lateral geniculate nuclei showed degeneration of layers 2, 3, and 5 on the right side (C) and of layers 1, 4, and 6 on the left side (D) (cresyl-violet, original magnification ×12 [insets: cresyl-violet, original magnification ×40]). IL indicates intercalated layer. ARTICLE INFORMATION Correction: This article was corrected on January 21, 2015, to fix an error in the figure. JAMA Ophthalmol. 2015;133(1):e141789. doi:10.1001/jamaophthalmol.2014.1789
jamaophthalmology.com Corrected on January 21, 2015
(Reprinted) JAMA Ophthalmology Published online January 8, 2015
Copyright 2015 American Medical Association. All rights reserved.
Downloaded From: http://archopht.jamanetwork.com/ by a Karolinska Institutet University Library User on 05/23/2015
1/1
