RESEARCH ARTICLE
Trend of Cardio-Metabolic Risk Factors in Polycystic Ovary Syndrome: A PopulationBased Prospective Cohort Study Fahimeh Ramezani Tehrani1¤*, Seyed Ali Montazeri1,5¤, Farhad Hosseinpanah2¤, Leila Cheraghi1¤, Hadi Erfani1,5¤, Maryam Tohidi3¤, Fereidoun Azizi4¤
a11111
1 Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 2 Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 3 Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 4 Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 5 Student of Public Health, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran ¤ Current address: Research Institute for Endocrine Sciences 24 Parvaneh, Yaman Street, Velenjak, P.O. Box 19395-4763, Tehran, I.R., Iran * [email protected]
OPEN ACCESS Citation: Ramezani Tehrani F, Montazeri SA, Hosseinpanah F, Cheraghi L, Erfani H, Tohidi M, et al. (2015) Trend of Cardio-Metabolic Risk Factors in Polycystic Ovary Syndrome: A Population-Based Prospective Cohort Study. PLoS ONE 10(9): e0137609. doi:10.1371/journal.pone.0137609 Editor: Cong Cao, Suzhou University, CHINA
Abstract Objective To see the changes of cardio-metabolic risk factors overtime in polycystic ovary syndrome vs. control women.
Received: April 27, 2015 Accepted: August 19, 2015
Methods
Published: September 11, 2015
This study was conducted on 637 participants (85 PCOS and 552 control reproductive aged, 18–45 years) of Tehran Lipid and Glucose Study (TLGS), an ongoing populationbased cohort study with 12 years of follow-up. The cardiovascular risk factors of these groups were assessed in three-year intervals using standard questionnaires, history taking, anthropometric measures, and metabolic/endocrine evaluation. Generalized estimating equation was used to analyze the data.
Copyright: © 2015 Ramezani Tehrani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: Third-party data are from the Tehran Lipid and Glucose study, whose authors may be contacted at Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran at azizi@endocrine. ac.ir. Funding: The National Council of Scientific Research of the Islamic Republic of Iran has approved and funded the TLGS as a national research project. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Results Overall mean of insulin (3.55, CI: 0.66–6.45), HOMA-IR (0.63, CI: 0.08–1.18), and HOMA-β (45.90, CI: 0.86–90.93) were significantly higher in PCOS than in healthy women after adjustment for age, BMI, and baseline levels. However, the negative interaction (follow-up years × PCOS status) of PCOS and normal women converged overtime. Comparing third follow-up with first, insulin and HOMA-IR decreased 10.6% and 5%, respectively in PCOS women; and increased 6.7% and 14.6%, respectively in controls (P
Trend of Cardio-Metabolic Risk Factors in Polycystic Ovary Syndrome: A PopulationBased Prospective Cohort Study Fahimeh Ramezani Tehrani1¤*, Seyed Ali Montazeri1,5¤, Farhad Hosseinpanah2¤, Leila Cheraghi1¤, Hadi Erfani1,5¤, Maryam Tohidi3¤, Fereidoun Azizi4¤
a11111
1 Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 2 Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 3 Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 4 Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 5 Student of Public Health, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran ¤ Current address: Research Institute for Endocrine Sciences 24 Parvaneh, Yaman Street, Velenjak, P.O. Box 19395-4763, Tehran, I.R., Iran * [email protected]
OPEN ACCESS Citation: Ramezani Tehrani F, Montazeri SA, Hosseinpanah F, Cheraghi L, Erfani H, Tohidi M, et al. (2015) Trend of Cardio-Metabolic Risk Factors in Polycystic Ovary Syndrome: A Population-Based Prospective Cohort Study. PLoS ONE 10(9): e0137609. doi:10.1371/journal.pone.0137609 Editor: Cong Cao, Suzhou University, CHINA
Abstract Objective To see the changes of cardio-metabolic risk factors overtime in polycystic ovary syndrome vs. control women.
Received: April 27, 2015 Accepted: August 19, 2015
Methods
Published: September 11, 2015
This study was conducted on 637 participants (85 PCOS and 552 control reproductive aged, 18–45 years) of Tehran Lipid and Glucose Study (TLGS), an ongoing populationbased cohort study with 12 years of follow-up. The cardiovascular risk factors of these groups were assessed in three-year intervals using standard questionnaires, history taking, anthropometric measures, and metabolic/endocrine evaluation. Generalized estimating equation was used to analyze the data.
Copyright: © 2015 Ramezani Tehrani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: Third-party data are from the Tehran Lipid and Glucose study, whose authors may be contacted at Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran at azizi@endocrine. ac.ir. Funding: The National Council of Scientific Research of the Islamic Republic of Iran has approved and funded the TLGS as a national research project. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Results Overall mean of insulin (3.55, CI: 0.66–6.45), HOMA-IR (0.63, CI: 0.08–1.18), and HOMA-β (45.90, CI: 0.86–90.93) were significantly higher in PCOS than in healthy women after adjustment for age, BMI, and baseline levels. However, the negative interaction (follow-up years × PCOS status) of PCOS and normal women converged overtime. Comparing third follow-up with first, insulin and HOMA-IR decreased 10.6% and 5%, respectively in PCOS women; and increased 6.7% and 14.6%, respectively in controls (P
