HHS Public Access Author manuscript Author Manuscript
Am Heart J. Author manuscript; available in PMC 2017 February 01. Published in final edited form as: Am Heart J. 2016 February ; 172: 53–63. doi:10.1016/j.ahj.2015.10.022.
Trends in Hospitalization for Takotsubo Cardiomyopathy in the United States Rohan Khera, MD1, KellyAnn Light-McGroary, MD2, Firas Zahr, MD2, Phillip A. Horwitz, MD2, and Saket Girotra, MD, SM2,3 1Department
of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA
Author Manuscript
2Division
of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 3Institute
of Clinical and Translational Science (ICTS), University of Iowa Carver College of Medicine, Iowa City, IA
Abstract Background—Takotsubo (or stress-induced) cardiomyopathy is characterized by transient left ventricular systolic dysfunction. Recent trends in patient volume, characteristics and outcomes in the United States are unknown.
Author Manuscript
Methods—Using 2007–2012 National Inpatient Sample data, we identified 22,005 adults (≥18 years) with a primary and 31,942 adults with a secondary discharge diagnosis of takotsubo cardiomyopathy (ICD-9 code 429.83) who underwent diagnostic coronary angiography. Results—During 2007–2012, the incidence of takotsubo cardiomyopathy increased over 3-fold: 52/million discharges in 2007 to 178/million in 2012 (P < 0.001). We found a temporal increase in the prevalence of cardiac arrest, cardiogenic shock, cardiovascular risk factors (diabetes, hypertension) and psychiatric disorders (P trend
Am Heart J. Author manuscript; available in PMC 2017 February 01. Published in final edited form as: Am Heart J. 2016 February ; 172: 53–63. doi:10.1016/j.ahj.2015.10.022.
Trends in Hospitalization for Takotsubo Cardiomyopathy in the United States Rohan Khera, MD1, KellyAnn Light-McGroary, MD2, Firas Zahr, MD2, Phillip A. Horwitz, MD2, and Saket Girotra, MD, SM2,3 1Department
of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA
Author Manuscript
2Division
of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 3Institute
of Clinical and Translational Science (ICTS), University of Iowa Carver College of Medicine, Iowa City, IA
Abstract Background—Takotsubo (or stress-induced) cardiomyopathy is characterized by transient left ventricular systolic dysfunction. Recent trends in patient volume, characteristics and outcomes in the United States are unknown.
Author Manuscript
Methods—Using 2007–2012 National Inpatient Sample data, we identified 22,005 adults (≥18 years) with a primary and 31,942 adults with a secondary discharge diagnosis of takotsubo cardiomyopathy (ICD-9 code 429.83) who underwent diagnostic coronary angiography. Results—During 2007–2012, the incidence of takotsubo cardiomyopathy increased over 3-fold: 52/million discharges in 2007 to 178/million in 2012 (P < 0.001). We found a temporal increase in the prevalence of cardiac arrest, cardiogenic shock, cardiovascular risk factors (diabetes, hypertension) and psychiatric disorders (P trend
