Pharmacological Research, Vol. 25, Supplement 1, 1992
73
TUMOR INHIBITION AND EFFECTS ON HOST SURVIVAL TIME BY RUTHENIUM" AND RHODIUM" COMPLEXES WITH DIMETHYLSULPHOXIDE LIGANDS S. PACOR, G. SAVA, G. MESTRONI* , E. ALESSIO* Istituto di Farmacologja, Facoky di Farmacia e M Dipartimento di Scienze Chimiche, University di Trieste. Key words: rhodium", ruthenium"', antitumor, Lewis lung carcinoma . Cis-dichlorodiammineplatinum° (Cisplatin) represents the best achievement of antitumor chemotherapy of the last 20 years ; nevertheless, it has a number of limitations of use due to severe side-effects and to unresponsiveness of tumors with great impact for human health, such as colo-rectal tumors. The experience of last years indicates ruthenium complexes as possible alternatives (1-4) . The aim of the present investigation was that of examining a series of rutheniumiii and rhodium°' complexes, characterized by the presence of dimethylsulphoxide ligands, on the Lewis lung carcinoma of BD2F I mice model . Treatment was performed by intraperitoneal administration of 0 .1mi/lOg body weight of distilled water containing the compound freshly dissolved immediately prior to inoculation . The effects on tumor growth were determined by measuring tumor volume at the end of treatment according to the formula : A2xBxN6), [A and B are two perpendicular axes (A
73
TUMOR INHIBITION AND EFFECTS ON HOST SURVIVAL TIME BY RUTHENIUM" AND RHODIUM" COMPLEXES WITH DIMETHYLSULPHOXIDE LIGANDS S. PACOR, G. SAVA, G. MESTRONI* , E. ALESSIO* Istituto di Farmacologja, Facoky di Farmacia e M Dipartimento di Scienze Chimiche, University di Trieste. Key words: rhodium", ruthenium"', antitumor, Lewis lung carcinoma . Cis-dichlorodiammineplatinum° (Cisplatin) represents the best achievement of antitumor chemotherapy of the last 20 years ; nevertheless, it has a number of limitations of use due to severe side-effects and to unresponsiveness of tumors with great impact for human health, such as colo-rectal tumors. The experience of last years indicates ruthenium complexes as possible alternatives (1-4) . The aim of the present investigation was that of examining a series of rutheniumiii and rhodium°' complexes, characterized by the presence of dimethylsulphoxide ligands, on the Lewis lung carcinoma of BD2F I mice model . Treatment was performed by intraperitoneal administration of 0 .1mi/lOg body weight of distilled water containing the compound freshly dissolved immediately prior to inoculation . The effects on tumor growth were determined by measuring tumor volume at the end of treatment according to the formula : A2xBxN6), [A and B are two perpendicular axes (A
