Distal pancreatectomy: M. C. Aldridge and I?.C. N. Williamson
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Paper accepted 18 March 1991
Case report Br. J. Surg. 1991, Vol. 78, August. 979-980
Tumours of the liver, bile ducts, pancreas and duodenum in a single patient with familial adenomatous polyposis A. D. Spigelman, K. C. R. Farmer, M. James, P. I. Richman and R . K. S. Phillips St. Mark's Hospital, City Road, London and St. Bartholomew's Hospital, West Smithfield, London, UK Correspondence to: Mr R. K. S. Phillips, St. Mark's Hospital, City Road, London E C I V 2PS, UK
The distribution of tumours in the upper gastrointestinal tract in patients with familial adenomatous polyposis parallels mucosal exposure to bile'. The presence of duodenal, pancreatic, bile duct, gallbladder and liver tumours in a patient with polyposis is reported here.
Case report A 78-year-old male with familial adenomatous polyposis presented with
a 12-month history of weight loss and a 2-month history of epigastric abdominal pain. The patient had undergone colectomy and ileorectal anastomosis at 41 years of age. Upper gastrointestinal endoscopy revealed Stage IV duodenal polyposis'. The largest adenoma was 15 mm in diameter and was next to the papilla of Vater. Abdominal ultrasonography revealed a 2-cm mass in the head of the pancreas and multiple hypoechoic lesions in the liver. Computed tomographic-guided biopsy of the liver showed the presence of adenocarcinoma. The patient developed obstructive jaundice and died 7 weeks later. Post mortem jindings The liver was studded with numerous nodules. The common bile duct contained two tumours. The first, just below the junction of the right and left hepatic ducts, caused obstruction. The second tumour was 3 cm above the ampulla. Underlying the latter lesion was a hard, 3-cm
0007-1323/91~080979-02 7 1991 Butterworth-Heinemann Ltd
mass within the head of the pancreas with proximal pancreatic duct dilatation. The gallbladder was thickened and had an irregular mucosal surface. Lymphadenopathy was present in the porta hepatis. above the pancreas and around the aorta. The adrenal glands contained nodules. The oesophagus contained numerous sessile oesophageal polyps ( ~ 0 . cm 7 in diameter). The second and third parts of' the duodenum contained five polyps ( < 1.5 cm in diameter), and the rectal stump contained two polyps (