Clinical Nutrition xxx (2013) 1e6

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Clinical Nutrition journal homepage: http://www.elsevier.com/locate/clnu

Original article

Upper-body obese women are resistant to postprandial stimulation of protein synthesisq Felix Liebau a, *, Michael D. Jensen b, K. Sreekumaran Nair b, Olav Rooyackers a a b

Department of Anesthesiology and Intensive Care, Karolinska University Hospital Huddinge and Karolinska Institutet, Stockholm, Sweden Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA

a r t i c l e i n f o

s u m m a r y

Article history: Received 14 February 2013 Accepted 1 November 2013

Background & aims: Upper-body, i.e. visceral, obesity is associated with insulin resistance and impaired protein synthesis. It is unclear whether postprandial stimulation of protein synthesis is affected by body fat distribution. We investigated the postprandial protein anabolic response in a cohort of obese women. Methods: Participants were studied after an overnight fast and after a mixed meal, grouped as upperbody obese (UBO, waist-to-hip ratio, WHR, >0.85, n ¼ 6) vs. lower-body obese (LBO, WHR

Upper-body obese women are resistant to postprandial stimulation of protein synthesis.

Upper-body, i.e. visceral, obesity is associated with insulin resistance and impaired protein synthesis. It is unclear whether postprandial stimulatio...
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