Diabetes Research atzd Clinical Practice. 17 (1992) 55-60 0
1992 Elsevier Science Publishers
55
B.V. All rights reserved 016%8227/92/$05.00
DIABET 00648
Urinary albumin excretion rate (AER) in newly-diagnosed type 2 Indian diabetic patients is associated with central obesity and hyperglycaemia C.S. Yajnik, S.S. Naik, K.N. Raut, A.D. Khade, D.S. Bhat, V.D. Nagarkar, J.A. Deshpande and K.M. Shelgikar Wellcome Diabetes Study. King Edward Memorial Hospital. Pune 411 01 I, India
(Received 21 October 1991) (Revision accepted 20 February 1992)
Summary Urinary albumin excretion rate (AER) was measured in non-diabetic controls (n = 143) and newly diagnosed impaired glucose tolerant (IGT, n = 64) and non-insulin-dependent (type 2) diabetic patients (n = 146). AER progressively increased from non-diabetic [3.7 (1.1-51.3) pg/min, median (5-95th centile)] to IGT [4.8 (1.3-53.7)] and diabetic [7.3 (1.4-91.6)] groups. Eight percent of non-diabetic, 19% of IGT and 23:; of type 2 diabetic patients showed ‘microalbuminuria’ (AER, 20-200 pg/min) (nondiabetic vs diabetic PtO.O1, non-diabetic vs IGT NS, IGT vs diabetic NS). AER was directly related to waist-hip ratio (P S/HPF as well
TABLE
1
Characteristics
of subjects studied
Age (years) Men,women BMI (kg/m”) W-H ratio Systolic blood pressure (mmHg) Diastolic blood pressure (mmHg) Fasting plasma glucose (mmol/l) HbA, (“0) AER (pg/min) Median
(5-95th
Non-diabetic (II = 143)
Impaired glucose tolerant (n = 64)
Type 2 diabetic (n = 146)
39 (23-59) 88,55 23.6 (17.1-29.7) 0.84 (0.71-0.97) 120 (100-150) 78 (60-96)
47 (29-63) 37.27 26.0 (19.0-33.0)” 0.88 (0.75-0.98)” 126 (106-160) 80 (64- 100)
45 (30-60) 92,54 24.2 ( 19.4-32.9)“~b 0.89 (0.74- 1.04)” 130 (104-163) 84 (66-102)8
4.6 (3.8-5.6)
5.1 (4.1-6.2)’
9.0 (5.2-15.6)“.”
6.1 (5.1-7.1)
6.8 (5.4-9.1)” 4.8 (1.3-53.7)
8.9 (6.5-14.0)‘1.h 7.3 ( 1.4-91.6)LL.h
3.7 (1.1-51.3) percentile);
’ P
1992 Elsevier Science Publishers
55
B.V. All rights reserved 016%8227/92/$05.00
DIABET 00648
Urinary albumin excretion rate (AER) in newly-diagnosed type 2 Indian diabetic patients is associated with central obesity and hyperglycaemia C.S. Yajnik, S.S. Naik, K.N. Raut, A.D. Khade, D.S. Bhat, V.D. Nagarkar, J.A. Deshpande and K.M. Shelgikar Wellcome Diabetes Study. King Edward Memorial Hospital. Pune 411 01 I, India
(Received 21 October 1991) (Revision accepted 20 February 1992)
Summary Urinary albumin excretion rate (AER) was measured in non-diabetic controls (n = 143) and newly diagnosed impaired glucose tolerant (IGT, n = 64) and non-insulin-dependent (type 2) diabetic patients (n = 146). AER progressively increased from non-diabetic [3.7 (1.1-51.3) pg/min, median (5-95th centile)] to IGT [4.8 (1.3-53.7)] and diabetic [7.3 (1.4-91.6)] groups. Eight percent of non-diabetic, 19% of IGT and 23:; of type 2 diabetic patients showed ‘microalbuminuria’ (AER, 20-200 pg/min) (nondiabetic vs diabetic PtO.O1, non-diabetic vs IGT NS, IGT vs diabetic NS). AER was directly related to waist-hip ratio (P S/HPF as well
TABLE
1
Characteristics
of subjects studied
Age (years) Men,women BMI (kg/m”) W-H ratio Systolic blood pressure (mmHg) Diastolic blood pressure (mmHg) Fasting plasma glucose (mmol/l) HbA, (“0) AER (pg/min) Median
(5-95th
Non-diabetic (II = 143)
Impaired glucose tolerant (n = 64)
Type 2 diabetic (n = 146)
39 (23-59) 88,55 23.6 (17.1-29.7) 0.84 (0.71-0.97) 120 (100-150) 78 (60-96)
47 (29-63) 37.27 26.0 (19.0-33.0)” 0.88 (0.75-0.98)” 126 (106-160) 80 (64- 100)
45 (30-60) 92,54 24.2 ( 19.4-32.9)“~b 0.89 (0.74- 1.04)” 130 (104-163) 84 (66-102)8
4.6 (3.8-5.6)
5.1 (4.1-6.2)’
9.0 (5.2-15.6)“.”
6.1 (5.1-7.1)
6.8 (5.4-9.1)” 4.8 (1.3-53.7)
8.9 (6.5-14.0)‘1.h 7.3 ( 1.4-91.6)LL.h
3.7 (1.1-51.3) percentile);
’ P
