progression to total occlusion by 5 years should read 24 of 39 patients (62%). The proportion of patients progressing to total occlusion without clinical evidence of infarction was statistically similar at 3 and 5 years (p = 0.39). Collateral circulation was noted in 83% of patients at 3 years and in 92% at 5 years. Inspection of Table IV of our paper reveals a general correspondence between the degree of stenosis and the incidence of subsequent progressionto total occlusion in this REPLY: Studies by Little,’ Am- postinfarction population. Albrose2and their co-workers have es- though lesions with minimal stenotablished that myocardial infarc- sis infrequently progressedto comtion frequently results from pro- plete occlusion, the cumulative risk gression of coronary lesions 90% and a 3-year infarction rate of only 2% for lesions of the left 1. Little WC, Constantinescu M, Appleanterior descending coronary ar- gate RJ, Kutcher MA, Burrows MT, tery with