Osteoporos Int DOI 10.1007/s00198-015-3168-0
ORIGINAL ARTICLE
Use of proton pump inhibitors is associated with fractures in young adults: a population-based study D. E. Freedberg 1 & K. Haynes 2 & M. R. Denburg 3 & B. S. Zemel 4 & M. B. Leonard 5 & J. A. Abrams 1 & Y.-X. Yang 2,6
Received: 2 March 2015 / Accepted: 6 May 2015 # International Osteoporosis Foundation and National Osteoporosis Foundation 2015
Abstract Summary Proton pump inhibitors (PPIs) are associated with risk for fracture in osteoporotic adults. In this populationbased study, we found a significant association between PPIs and fracture in young adults, with evidence of a dose–response effect. Young adults who use PPIs should be cautioned regarding risk for fracture. Introduction Proton pump inhibitors (PPIs) are associated with fracture in adults with osteoporosis. Because PPI therapy may interfere with bone accrual and attainment of peak bone mineral density, we studied the association between use of PPIs and fracture in children and young adults.
Electronic supplementary material The online version of this article (doi:10.1007/s00198-015-3168-0) contains supplementary material, which is available to authorized users. * D. E. Freedberg [email protected]
Methods We conducted a population-based, case–control study nested within records from general medical practices from 1994 to 2013. Participants were 4–29 years old with ≥1 year of follow-up who lacked chronic conditions associated with use of long-term acid suppression. Cases of fracture were defined as the first incident fracture at any site. Using incidence density sampling, cases were matched with up to five controls by age, sex, medical practice, and start of follow-up. PPI exposure was defined as 180 or more cumulative doses of PPIs. Conditional logistic regression was used to estimate the odds ratio and confidence interval for use of PPIs and fracture. Results We identified 124,799 cases and 605,643 controls. The adjusted odds ratio for the risk of fracture associated with PPI exposure was 1.13 (95 % CI 0.92 to 1.39) among children aged
ORIGINAL ARTICLE
Use of proton pump inhibitors is associated with fractures in young adults: a population-based study D. E. Freedberg 1 & K. Haynes 2 & M. R. Denburg 3 & B. S. Zemel 4 & M. B. Leonard 5 & J. A. Abrams 1 & Y.-X. Yang 2,6
Received: 2 March 2015 / Accepted: 6 May 2015 # International Osteoporosis Foundation and National Osteoporosis Foundation 2015
Abstract Summary Proton pump inhibitors (PPIs) are associated with risk for fracture in osteoporotic adults. In this populationbased study, we found a significant association between PPIs and fracture in young adults, with evidence of a dose–response effect. Young adults who use PPIs should be cautioned regarding risk for fracture. Introduction Proton pump inhibitors (PPIs) are associated with fracture in adults with osteoporosis. Because PPI therapy may interfere with bone accrual and attainment of peak bone mineral density, we studied the association between use of PPIs and fracture in children and young adults.
Electronic supplementary material The online version of this article (doi:10.1007/s00198-015-3168-0) contains supplementary material, which is available to authorized users. * D. E. Freedberg [email protected]
Methods We conducted a population-based, case–control study nested within records from general medical practices from 1994 to 2013. Participants were 4–29 years old with ≥1 year of follow-up who lacked chronic conditions associated with use of long-term acid suppression. Cases of fracture were defined as the first incident fracture at any site. Using incidence density sampling, cases were matched with up to five controls by age, sex, medical practice, and start of follow-up. PPI exposure was defined as 180 or more cumulative doses of PPIs. Conditional logistic regression was used to estimate the odds ratio and confidence interval for use of PPIs and fracture. Results We identified 124,799 cases and 605,643 controls. The adjusted odds ratio for the risk of fracture associated with PPI exposure was 1.13 (95 % CI 0.92 to 1.39) among children aged
