RESEARCH ARTICLE
Use of Renal Replacement Therapy May Influence Graft Outcomes following Liver Transplantation for Acute Liver Failure: A Propensity-Score Matched Population-Based Retrospective Cohort Study Stephen R. Knight1, Gabriel C. Oniscu1, Luke Devey2, Kenneth J. Simpson1, Stephen J. Wigmore1, Ewen M. Harrison1* 1 Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom, 2 Pipeline Futures Group, GSK, 1250 South Collegeville Rd, Collegeville, Pennsylvania, 19426, United States of America * [email protected] OPEN ACCESS Citation: Knight SR, Oniscu GC, Devey L, Simpson KJ, Wigmore SJ, Harrison EM (2016) Use of Renal Replacement Therapy May Influence Graft Outcomes following Liver Transplantation for Acute Liver Failure: A Propensity-Score Matched Population-Based Retrospective Cohort Study. PLoS ONE 11(3): e0148782. doi:10.1371/journal.pone.0148782 Editor: Guy N Brock, Ohio State University College of Medicine, UNITED STATES Received: August 15, 2015 Accepted: January 22, 2016 Published: March 1, 2016 Copyright: © 2016 Knight et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: The study in itself does not involve the use of donated tissue and/or organs. This is a registry study of anonymised donors and recipients from data routinely collected by NHSBT. The donors and/or donor families have consented/ assented to the use of tissues for transplantation and recipients have undergone a formal consent process prior to transplantation. The study data is available on request from National Health Service Blood and Transplant (NHSBT). NHSBT collects, records and analyses data concerning potential and actual organ
Abstract Introduction Acute kidney injury is associated with a poor prognosis in acute liver failure but little is known of outcomes in patients undergoing transplantation for acute liver failure who require renal replacement therapy.
Methods A retrospective analysis of the United Kingdom Transplant Registry was performed (1 January 2001–31 December 2011) with patient and graft survival determined using KaplanMeier methods. Cox proportional hazards models were used together with propensity-score based full matching on renal replacement therapy use.
Results Three-year patient and graft survival for patients receiving renal replacement therapy were 77.7% and 72.6% compared with 85.1% and 79.4% for those not requiring renal replacement therapy (P
Use of Renal Replacement Therapy May Influence Graft Outcomes following Liver Transplantation for Acute Liver Failure: A Propensity-Score Matched Population-Based Retrospective Cohort Study Stephen R. Knight1, Gabriel C. Oniscu1, Luke Devey2, Kenneth J. Simpson1, Stephen J. Wigmore1, Ewen M. Harrison1* 1 Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom, 2 Pipeline Futures Group, GSK, 1250 South Collegeville Rd, Collegeville, Pennsylvania, 19426, United States of America * [email protected] OPEN ACCESS Citation: Knight SR, Oniscu GC, Devey L, Simpson KJ, Wigmore SJ, Harrison EM (2016) Use of Renal Replacement Therapy May Influence Graft Outcomes following Liver Transplantation for Acute Liver Failure: A Propensity-Score Matched Population-Based Retrospective Cohort Study. PLoS ONE 11(3): e0148782. doi:10.1371/journal.pone.0148782 Editor: Guy N Brock, Ohio State University College of Medicine, UNITED STATES Received: August 15, 2015 Accepted: January 22, 2016 Published: March 1, 2016 Copyright: © 2016 Knight et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: The study in itself does not involve the use of donated tissue and/or organs. This is a registry study of anonymised donors and recipients from data routinely collected by NHSBT. The donors and/or donor families have consented/ assented to the use of tissues for transplantation and recipients have undergone a formal consent process prior to transplantation. The study data is available on request from National Health Service Blood and Transplant (NHSBT). NHSBT collects, records and analyses data concerning potential and actual organ
Abstract Introduction Acute kidney injury is associated with a poor prognosis in acute liver failure but little is known of outcomes in patients undergoing transplantation for acute liver failure who require renal replacement therapy.
Methods A retrospective analysis of the United Kingdom Transplant Registry was performed (1 January 2001–31 December 2011) with patient and graft survival determined using KaplanMeier methods. Cox proportional hazards models were used together with propensity-score based full matching on renal replacement therapy use.
Results Three-year patient and graft survival for patients receiving renal replacement therapy were 77.7% and 72.6% compared with 85.1% and 79.4% for those not requiring renal replacement therapy (P
