HHS Public Access Author manuscript Author Manuscript
Neurotoxicology. Author manuscript; available in PMC 2017 October 02. Published in final edited form as: Neurotoxicology. 2017 September ; 62: 124–129. doi:10.1016/j.neuro.2017.06.008.
Vanadium exposure-induced striatal learning and memory alterations in rats Liping Suna,b, Keyue Wanga, Yan Lia, Qiyuan Fana, Wei Zhengc, and Hong Lia,* aSchool bAn
of Public Health, Zunyi Medical University, Zunyi, Guizhou, 563000, China
Yang Center for Disease Control and Prevention, Anyang, Henan, 455000, China
Author Manuscript
cSchool
of Health Sciences, Purdue University, West Lafayette, IN, 47907, USA
Abstract
Author Manuscript
Occupational and environmental exposure to vanadium has been associated with toxicities in reproductive, respiratory, and cardiovascular systems. The knowledge on whether and how vanadium exposure caused neurobehavioral changes remains incomplete. This study was designed to investigate the changes in learning and memory following drinking water exposure to vanadium, and to conduct the preliminary study on underlying mechanisms. Male Sprague-Dawley rats were exposed to vanadium dissolved in drinking water at the concentration of 0.0, 0.5, 1.0 and 2.0 g/L, as the control, low-, medium-, and high- dose groups, respectively, for 12 weeks. The results by the Morris water maze test showed that the time for the testing animal to find the platform in the high exposed group was increased by 82.9% and 49.7%, as compared to animals in control and low-dose groups (p
Neurotoxicology. Author manuscript; available in PMC 2017 October 02. Published in final edited form as: Neurotoxicology. 2017 September ; 62: 124–129. doi:10.1016/j.neuro.2017.06.008.
Vanadium exposure-induced striatal learning and memory alterations in rats Liping Suna,b, Keyue Wanga, Yan Lia, Qiyuan Fana, Wei Zhengc, and Hong Lia,* aSchool bAn
of Public Health, Zunyi Medical University, Zunyi, Guizhou, 563000, China
Yang Center for Disease Control and Prevention, Anyang, Henan, 455000, China
Author Manuscript
cSchool
of Health Sciences, Purdue University, West Lafayette, IN, 47907, USA
Abstract
Author Manuscript
Occupational and environmental exposure to vanadium has been associated with toxicities in reproductive, respiratory, and cardiovascular systems. The knowledge on whether and how vanadium exposure caused neurobehavioral changes remains incomplete. This study was designed to investigate the changes in learning and memory following drinking water exposure to vanadium, and to conduct the preliminary study on underlying mechanisms. Male Sprague-Dawley rats were exposed to vanadium dissolved in drinking water at the concentration of 0.0, 0.5, 1.0 and 2.0 g/L, as the control, low-, medium-, and high- dose groups, respectively, for 12 weeks. The results by the Morris water maze test showed that the time for the testing animal to find the platform in the high exposed group was increased by 82.9% and 49.7%, as compared to animals in control and low-dose groups (p
