© 1991 S. Karger A G . Basel 0378-7346/91 /0314-0208S2.75/0

Gynecol Obstet Invest 1991;31:208-212

Vasoactive Effects of Intra- and Extravascular Serotonin, PGE2and PGF2a in Human Umbilical Arteries G. Haugen3, K. Bjaro'0, S. Stray-Pedersen3 •'Department o f Obstetrics and Gynecology and bInstitute o f Clinical Biochemistry, National Hospital, University o f Oslo, Norway-

Key Words. Perfusion ■PGE2 • PGF 2a • Serotonin • Umbilical artery • Endothelium Abstract. The effect of serotonin, PGE 2 and PGF 2a on the vascular tension in human umbilical arteries has been investigated during in vitro perfusions. All autacoids induced dose-dependent biphasic pressure responses when added to the perfusate. When added to the extraumbilical fluid, serotonin induced monophasic vasoconstrictory responses, whereas PGE2 and PGF 2

Vasoactive effects of intra- and extravascular serotonin, PGE2 and PGF2 alpha in human umbilical arteries.

The effect of serotonin, PGE2 and PGF2 alpha on the vascular tension in human umbilical arteries has been investigated during in vitro perfusions. All...
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