Int J Ophthalmol, Vol. 10, No. 2, Feb.18, 2017 www.ijo.cn Tel:8629-82245172 8629-82210956 Email:[email protected]
·Basic Research·
Vasoactive intestinal peptide, a promising agent for myopia? Ayse Idil Cakmak1, Hikmet Basmak1, Huseyin Gursoy1, Mete Ozkurt2, Nilgun Yildirim1, Nilufer Erkasap2, Mustafa Deger Bilgec1, Nese Tuncel2, Ertugrul Colak3 1
Department of Ophthalmology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey 2 Department of Physiology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey 3 Department of Biostatistics, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey Correspondence to: Huseyin Gursoy. Department of Ophthalmology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey. [email protected] Received: 2016-02-18 Accepted: 2016-07-18
Abstract
● AIM: To investigate the role of vasoactive intestinal peptide (VIP) in form-deprivation myopia (FDM). ● METHODS: FDM was created in three groups of eight chicks by placing a translucent diffuser on their right eyes. Intravitreal injections of saline and VIP were applied once a day into the occluded eyes of groups 2 and 3, respectively. Retinoscopy and axial length (AL) measurements were performed on the first and 8th days of diffuser wear. The retina mRNA levels of the VIP receptors and the ZENK protein in right eyes of the three groups and left eyes of the first group on day 8 were determined using real time polymerase chain reaction (PCR). ● RESULTS: The median final refraction (D) in right eyes were -13.75 (-16.00, -12.00), -11.50 (-12.50, -7.50), and -1.50 (-4.75, -0.75) in groups 1, 2, and 3, respectively (P
·Basic Research·
Vasoactive intestinal peptide, a promising agent for myopia? Ayse Idil Cakmak1, Hikmet Basmak1, Huseyin Gursoy1, Mete Ozkurt2, Nilgun Yildirim1, Nilufer Erkasap2, Mustafa Deger Bilgec1, Nese Tuncel2, Ertugrul Colak3 1
Department of Ophthalmology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey 2 Department of Physiology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey 3 Department of Biostatistics, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey Correspondence to: Huseyin Gursoy. Department of Ophthalmology, Eskisehir Osmangazi University Medical Faculty, Eskisehir 26180, Turkey. [email protected] Received: 2016-02-18 Accepted: 2016-07-18
Abstract
● AIM: To investigate the role of vasoactive intestinal peptide (VIP) in form-deprivation myopia (FDM). ● METHODS: FDM was created in three groups of eight chicks by placing a translucent diffuser on their right eyes. Intravitreal injections of saline and VIP were applied once a day into the occluded eyes of groups 2 and 3, respectively. Retinoscopy and axial length (AL) measurements were performed on the first and 8th days of diffuser wear. The retina mRNA levels of the VIP receptors and the ZENK protein in right eyes of the three groups and left eyes of the first group on day 8 were determined using real time polymerase chain reaction (PCR). ● RESULTS: The median final refraction (D) in right eyes were -13.75 (-16.00, -12.00), -11.50 (-12.50, -7.50), and -1.50 (-4.75, -0.75) in groups 1, 2, and 3, respectively (P
