Eur J Nutr (2016) 55:281–293 DOI 10.1007/s00394-015-0845-x
ORIGINAL CONTRIBUTION
Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh Towfida J. Siddiqua · Shaikh M. Ahmad · Khalid B. Ahsan · Mamunur Rashid · Anjan Roy · Syed M. Rahman · Setareh Shahab‑Ferdows · Daniela Hampel · Tahmeed Ahmed · Lindsay H. Allen · Rubhana Raqib Received: 28 April 2014 / Accepted: 26 January 2015 / Published online: 4 February 2015 © Springer-Verlag Berlin Heidelberg 2015
Abstract Purpose Poor vitamin B12 (B12) status is associated with adverse outcomes in pregnancy and infancy. Little is known about effects of B12 supplementation on immune function. The present study aimed to evaluate effects of pre- and postnatal B12 supplementation on biomarkers of B12 status and vaccine-specific responses in mothers and infants. Method In a blinded, placebo-controlled trial, Bangladeshi women (n = 68, age 18–35 years, hemoglobin 10 μmol/L). Supplementation increased B12 in plasma, colostrums and breast milk (p
ORIGINAL CONTRIBUTION
Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh Towfida J. Siddiqua · Shaikh M. Ahmad · Khalid B. Ahsan · Mamunur Rashid · Anjan Roy · Syed M. Rahman · Setareh Shahab‑Ferdows · Daniela Hampel · Tahmeed Ahmed · Lindsay H. Allen · Rubhana Raqib Received: 28 April 2014 / Accepted: 26 January 2015 / Published online: 4 February 2015 © Springer-Verlag Berlin Heidelberg 2015
Abstract Purpose Poor vitamin B12 (B12) status is associated with adverse outcomes in pregnancy and infancy. Little is known about effects of B12 supplementation on immune function. The present study aimed to evaluate effects of pre- and postnatal B12 supplementation on biomarkers of B12 status and vaccine-specific responses in mothers and infants. Method In a blinded, placebo-controlled trial, Bangladeshi women (n = 68, age 18–35 years, hemoglobin 10 μmol/L). Supplementation increased B12 in plasma, colostrums and breast milk (p
