Accepted Manuscript Vitamin D status in early pregnancy and risk of preeclampsia (E14-0363) Ms. Madonna Achkar , M.Sc., R.D, Ms. Linda Dodds , Ph.D, Dr. Yves Giguère , M.D, Ph.D, Dr. Jean-Claude Forest , M.D, Ph.D, Dr. B. Anthony Armson , M.D, M.Sc, Ms. Christy Woolcott , Ph.D, Ms. Sherry Agellon , M.Sc, Ms. Anne Spencer , M.Sc, Ms. Hope A. Weiler , Ph.D, R.D PII:
S0002-9378(14)02208-X
DOI:
10.1016/j.ajog.2014.11.009
Reference:
YMOB 10129
To appear in:
American Journal of Obstetrics and Gynecology
Received Date: 8 July 2014 Revised Date:
9 October 2014
Accepted Date: 4 November 2014
Please cite this article as: Achkar M, Dodds L, Giguère Y, Forest J-C, Armson BA, Woolcott C, Agellon S, Spencer A, Weiler HA, Vitamin D status in early pregnancy and risk of preeclampsia (E14-0363), American Journal of Obstetrics and Gynecology (2014), doi: 10.1016/j.ajog.2014.11.009. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Topic heading: Obstetrics Vitamin D status in early pregnancy and risk of preeclampsia (E14-0363) Ms. Madonna ACHKAR, M.Sc., R.D 1, Ms. Linda DODDS, Ph.D2, Dr. Yves GIGUÈRE, M.D,
RI PT
Ph.D3, Dr. Jean-Claude FOREST, M.D, Ph.D3, Dr. B. Anthony ARMSON, M.D, M.Sc4, Ms. Christy WOOLCOTT, Ph.D2, Ms. Sherry AGELLON, M.Sc1, Ms. Anne SPENCER, M.Sc2, Ms. Hope A. WEILER, Ph.D, R.D1
School of Dietetics and Human Nutrition, McGill University, Ste. Anne de Bellevue, QC,
SC
1
Canada;
Perinatal Epidemiology Research Unit, Dalhousie University and IWK Health Centre, Halifax,
M AN U
2
Nova Scotia, Canada; 3
CHU de Québec Research Center and Molecular Biology, Department of molecular and medical
biology, Faculty of Medicine, Université Laval, Quebec City, QC, Canada; Obstetrics & Gynaecology, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia,
Canada
TE D
4
Cities in which the study was conducted:
EP
Canada (Halifax, Nova Scotia; Quebec City, Quebec and Montreal, Quebec). The authors report no conflict of interest.
AC C
The authors acknowledge the Canadian Institute of Health Research for funding the study. This research was presented as a poster at the Réseau de recherché en santé buccodentaire et osseuse retreat on January 17th, 2014; at the 10th Interdisciplinary Graduate Research Symposium in Montreal, QC, on March 17th, 2014 (second place Award), and as an oral presentation at the Canadian National Perinatal Research Meeting in Banff, Alberta, Canada on February 15th, 2014. The word count of the abstract: 250 words; the word count of the main text: 2995 words.
1
ACCEPTED MANUSCRIPT
Corresponding author: Hope A. Weiler, RD, PhD
CRC tier II, Nutrition, Development and Aging School of Dietetics and Human Nutrition McGill University Macdonald Campus
SC
MS2042a Macdonald Stewart bldg
H9X 3V9 Phone: 514-398-7905 Fax: 514-398-7739
AC C
EP
TE D
Email address: [email protected]
M AN U
21111 Lakeshore Rd Ste Anne de Bellevue, QC
RI PT
Associate Professor
2
ACCEPTED MANUSCRIPT
Condensation and short version of title
•
Vitamin D deficiency before 20 weeks of gestation doubles the risk of preeclampsia:
EP
TE D
M AN U
SC
Vitamin D status and risk of preeclampsia.
AC C
•
RI PT
results from a nested case-control study from two large cohorts in Canada.
3
ACCEPTED MANUSCRIPT
Abstract Objectives: To examine the association between maternal serum 25-hydroxyvitamin D
RI PT
(25(OH)D) concentration in early pregnancy and the subsequent diagnosis of preeclampsia. Study design: A nested case-control study from two prospective Canadian cohorts conducted in Quebec City and Halifax between 2002 and 2010. Participants were pregnant women (n= 169 cases with preeclampsia and 1975 controls). Maternal serum was drawn before 20 weeks of
SC
gestation, and 25(OH)D measurement was performed. Cases were ascertained from medical
M AN U
records. Logistic regression analysis was used to estimate adjusted odds ratios [aOR] with 95% confidence intervals [CI].
Results: Women who developed preeclampsia had a significantly lower 25(OH)D concentration at a mean gestational age of 14 weeks compared with women in the control group (mean±SD 25(OH)D 47.2 ±17.7 versus 52.3 ±17.2 nmol/L, p
S0002-9378(14)02208-X
DOI:
10.1016/j.ajog.2014.11.009
Reference:
YMOB 10129
To appear in:
American Journal of Obstetrics and Gynecology
Received Date: 8 July 2014 Revised Date:
9 October 2014
Accepted Date: 4 November 2014
Please cite this article as: Achkar M, Dodds L, Giguère Y, Forest J-C, Armson BA, Woolcott C, Agellon S, Spencer A, Weiler HA, Vitamin D status in early pregnancy and risk of preeclampsia (E14-0363), American Journal of Obstetrics and Gynecology (2014), doi: 10.1016/j.ajog.2014.11.009. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Topic heading: Obstetrics Vitamin D status in early pregnancy and risk of preeclampsia (E14-0363) Ms. Madonna ACHKAR, M.Sc., R.D 1, Ms. Linda DODDS, Ph.D2, Dr. Yves GIGUÈRE, M.D,
RI PT
Ph.D3, Dr. Jean-Claude FOREST, M.D, Ph.D3, Dr. B. Anthony ARMSON, M.D, M.Sc4, Ms. Christy WOOLCOTT, Ph.D2, Ms. Sherry AGELLON, M.Sc1, Ms. Anne SPENCER, M.Sc2, Ms. Hope A. WEILER, Ph.D, R.D1
School of Dietetics and Human Nutrition, McGill University, Ste. Anne de Bellevue, QC,
SC
1
Canada;
Perinatal Epidemiology Research Unit, Dalhousie University and IWK Health Centre, Halifax,
M AN U
2
Nova Scotia, Canada; 3
CHU de Québec Research Center and Molecular Biology, Department of molecular and medical
biology, Faculty of Medicine, Université Laval, Quebec City, QC, Canada; Obstetrics & Gynaecology, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia,
Canada
TE D
4
Cities in which the study was conducted:
EP
Canada (Halifax, Nova Scotia; Quebec City, Quebec and Montreal, Quebec). The authors report no conflict of interest.
AC C
The authors acknowledge the Canadian Institute of Health Research for funding the study. This research was presented as a poster at the Réseau de recherché en santé buccodentaire et osseuse retreat on January 17th, 2014; at the 10th Interdisciplinary Graduate Research Symposium in Montreal, QC, on March 17th, 2014 (second place Award), and as an oral presentation at the Canadian National Perinatal Research Meeting in Banff, Alberta, Canada on February 15th, 2014. The word count of the abstract: 250 words; the word count of the main text: 2995 words.
1
ACCEPTED MANUSCRIPT
Corresponding author: Hope A. Weiler, RD, PhD
CRC tier II, Nutrition, Development and Aging School of Dietetics and Human Nutrition McGill University Macdonald Campus
SC
MS2042a Macdonald Stewart bldg
H9X 3V9 Phone: 514-398-7905 Fax: 514-398-7739
AC C
EP
TE D
Email address: [email protected]
M AN U
21111 Lakeshore Rd Ste Anne de Bellevue, QC
RI PT
Associate Professor
2
ACCEPTED MANUSCRIPT
Condensation and short version of title
•
Vitamin D deficiency before 20 weeks of gestation doubles the risk of preeclampsia:
EP
TE D
M AN U
SC
Vitamin D status and risk of preeclampsia.
AC C
•
RI PT
results from a nested case-control study from two large cohorts in Canada.
3
ACCEPTED MANUSCRIPT
Abstract Objectives: To examine the association between maternal serum 25-hydroxyvitamin D
RI PT
(25(OH)D) concentration in early pregnancy and the subsequent diagnosis of preeclampsia. Study design: A nested case-control study from two prospective Canadian cohorts conducted in Quebec City and Halifax between 2002 and 2010. Participants were pregnant women (n= 169 cases with preeclampsia and 1975 controls). Maternal serum was drawn before 20 weeks of
SC
gestation, and 25(OH)D measurement was performed. Cases were ascertained from medical
M AN U
records. Logistic regression analysis was used to estimate adjusted odds ratios [aOR] with 95% confidence intervals [CI].
Results: Women who developed preeclampsia had a significantly lower 25(OH)D concentration at a mean gestational age of 14 weeks compared with women in the control group (mean±SD 25(OH)D 47.2 ±17.7 versus 52.3 ±17.2 nmol/L, p
