Accepted Manuscript Title: Volumetric changes in amygdala and entorhinal cortex and their relation to memory impairment in patients with medial temporal lobe epilepsy with visually normal MR imaging findings Author: Bingwei Peng Liwen Wu Lihua Zhang Yan Chen PII: DOI: Reference:
S0920-1211(15)00091-1 http://dx.doi.org/doi:10.1016/j.eplepsyres.2015.04.018 EPIRES 5371
To appear in:
Epilepsy Research
Received date: Revised date: Accepted date:
20-1-2015 18-4-2015 23-4-2015
Please cite this article as: Peng, Bingwei, Wu, Liwen, Zhang, Lihua, Chen, Yan, Volumetric changes in amygdala and entorhinal cortex and their relation to memory impairment in patients with medial temporal lobe epilepsy with visually normal MR imaging findings.Epilepsy Research http://dx.doi.org/10.1016/j.eplepsyres.2015.04.018 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Volumetric changes in amygdala and entorhinal cortex and their relation to memory impairment in patients with medial temporal lobe epilepsy with visually normal MR imaging findings
Bingwei Peng*,1, Liwen Wu, Lihua Zhang, and Yan Chen
Department of Neurology, Peking Union Medical College Hospital 1
Current affiliation: Department of Neurology, Guang Zhou Women and Children’s
Medical Center
*Corresponding author – E-mail: [email protected]; phone: 008613060845449 Additional authors’ email addresses: Liwen Wu: [email protected] Lihua Zhang: [email protected] Yan Chen: [email protected]
Abstract
Objective: To explore the relation between parahippocampal structures, such as the amygdala and the entorhinal cortex (EC), with verbal and nonverbal memory in patients with medial temporal lobe epilepsy (MTLE) with visually normal MR imaging findings by volumetric measurements using magnetic resonance imaging (MRI). Methods: Thirty-six consecutive patients with MTLE presenting a non-sclerotic hippocampus though visual inspection were assessed by MRI to measure the volumes of the hippocampus, amygdale and EC, and by using the Clinical Memory Scale (CMS), a test battery for verbal and nonverbal memory, where summation of all CMS subscale scores equals the memory quotient (MQ). The correlations between MRI volumetric data (Z scores or asymmetry indexes (AI; (L-R) / (L+R)), “L” and “R” refer to the left and right volumes of each structure, respectively), clinical variables and memory scale scores were analyzed using a
principal component regression model. Results: Volumetric MRI revealed significant differences between the volumes of the hippocampus, EC, and right amygdala, but no differences in the volume of the left amygdala between the controls and the patients group. The patients group performed significantly worse in MQ (p
S0920-1211(15)00091-1 http://dx.doi.org/doi:10.1016/j.eplepsyres.2015.04.018 EPIRES 5371
To appear in:
Epilepsy Research
Received date: Revised date: Accepted date:
20-1-2015 18-4-2015 23-4-2015
Please cite this article as: Peng, Bingwei, Wu, Liwen, Zhang, Lihua, Chen, Yan, Volumetric changes in amygdala and entorhinal cortex and their relation to memory impairment in patients with medial temporal lobe epilepsy with visually normal MR imaging findings.Epilepsy Research http://dx.doi.org/10.1016/j.eplepsyres.2015.04.018 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Volumetric changes in amygdala and entorhinal cortex and their relation to memory impairment in patients with medial temporal lobe epilepsy with visually normal MR imaging findings
Bingwei Peng*,1, Liwen Wu, Lihua Zhang, and Yan Chen
Department of Neurology, Peking Union Medical College Hospital 1
Current affiliation: Department of Neurology, Guang Zhou Women and Children’s
Medical Center
*Corresponding author – E-mail: [email protected]; phone: 008613060845449 Additional authors’ email addresses: Liwen Wu: [email protected] Lihua Zhang: [email protected] Yan Chen: [email protected]
Abstract
Objective: To explore the relation between parahippocampal structures, such as the amygdala and the entorhinal cortex (EC), with verbal and nonverbal memory in patients with medial temporal lobe epilepsy (MTLE) with visually normal MR imaging findings by volumetric measurements using magnetic resonance imaging (MRI). Methods: Thirty-six consecutive patients with MTLE presenting a non-sclerotic hippocampus though visual inspection were assessed by MRI to measure the volumes of the hippocampus, amygdale and EC, and by using the Clinical Memory Scale (CMS), a test battery for verbal and nonverbal memory, where summation of all CMS subscale scores equals the memory quotient (MQ). The correlations between MRI volumetric data (Z scores or asymmetry indexes (AI; (L-R) / (L+R)), “L” and “R” refer to the left and right volumes of each structure, respectively), clinical variables and memory scale scores were analyzed using a
principal component regression model. Results: Volumetric MRI revealed significant differences between the volumes of the hippocampus, EC, and right amygdala, but no differences in the volume of the left amygdala between the controls and the patients group. The patients group performed significantly worse in MQ (p
