RESEARCH ARTICLE
A Five-Year Prospective Study of Diabetic Retinopathy Progression in Chinese Type 2 Diabetes Patients with “Well-Controlled” Blood Glucose Peiyao Jin1, Jinjuan Peng1, Haidong Zou1,2*, Weiwei Wang3, Jiong Fu3, Binjie Shen3, Xuelin Bai3, Xun Xu1, Xi Zhang1 1 Department of Ophthalmology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai, 20080, China, 2 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai, 200040, China, 3 Beixinjing Community Health Service Center, Shanghai, China * [email protected]
Abstract OPEN ACCESS Citation: Jin P, Peng J, Zou H, Wang W, Fu J, Shen B, et al. (2015) A Five-Year Prospective Study of Diabetic Retinopathy Progression in Chinese Type 2 Diabetes Patients with “Well-Controlled” Blood Glucose. PLoS ONE 10(4): e0123449. doi:10.1371/ journal.pone.0123449
Purpose To determine the progression rate and risk factors for diabetic retinopathy (DR) in Chinese type 2 diabetic patients who have reached the target hemoglobin A1c (HbA1c) level recommended by the American Diabetes Association.
Academic Editor: Mingguang He, Zhongshan Ophthalmic Center, CHINA Received: June 20, 2014
Methods
Accepted: March 3, 2015
This was a 5-year community-based prospective study. The study population consisted of patients with type 2 diabetes with HbA1c less than 7.0%. Demographic information, systemic examination results and ophthalmological test results for each participant were collected. The outcome of this study was the progression of DR, which was defined as an increase in DR grade in one or both eyes at the final visit in comparison to the baseline status. The association between each potential risk factor and DR progression was studied.
Published: April 7, 2015 Copyright: © 2015 Jin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper.
Results
Funding: This study was funded by the Chinese National Nature Science Foundation (project number 81371069), Shanghai Pujiang Program (project number PJ(2012) 0001652), Shanghai New Hundred Talents Program from Shanghai Medical and Family Planning Commitee (project number 13B141). The sponsor or funding organization had no role in the design or conduct of this research.
A total of 453 patients with HbA1c less than 7.0% were included in the study group. In 146 patients (32.22%), DR developed or progressed during the five-year follow-up. Baseline HbA1c level was the only independent risk factor for DR progression (p
A Five-Year Prospective Study of Diabetic Retinopathy Progression in Chinese Type 2 Diabetes Patients with “Well-Controlled” Blood Glucose Peiyao Jin1, Jinjuan Peng1, Haidong Zou1,2*, Weiwei Wang3, Jiong Fu3, Binjie Shen3, Xuelin Bai3, Xun Xu1, Xi Zhang1 1 Department of Ophthalmology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai, 20080, China, 2 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai, 200040, China, 3 Beixinjing Community Health Service Center, Shanghai, China * [email protected]
Abstract OPEN ACCESS Citation: Jin P, Peng J, Zou H, Wang W, Fu J, Shen B, et al. (2015) A Five-Year Prospective Study of Diabetic Retinopathy Progression in Chinese Type 2 Diabetes Patients with “Well-Controlled” Blood Glucose. PLoS ONE 10(4): e0123449. doi:10.1371/ journal.pone.0123449
Purpose To determine the progression rate and risk factors for diabetic retinopathy (DR) in Chinese type 2 diabetic patients who have reached the target hemoglobin A1c (HbA1c) level recommended by the American Diabetes Association.
Academic Editor: Mingguang He, Zhongshan Ophthalmic Center, CHINA Received: June 20, 2014
Methods
Accepted: March 3, 2015
This was a 5-year community-based prospective study. The study population consisted of patients with type 2 diabetes with HbA1c less than 7.0%. Demographic information, systemic examination results and ophthalmological test results for each participant were collected. The outcome of this study was the progression of DR, which was defined as an increase in DR grade in one or both eyes at the final visit in comparison to the baseline status. The association between each potential risk factor and DR progression was studied.
Published: April 7, 2015 Copyright: © 2015 Jin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper.
Results
Funding: This study was funded by the Chinese National Nature Science Foundation (project number 81371069), Shanghai Pujiang Program (project number PJ(2012) 0001652), Shanghai New Hundred Talents Program from Shanghai Medical and Family Planning Commitee (project number 13B141). The sponsor or funding organization had no role in the design or conduct of this research.
A total of 453 patients with HbA1c less than 7.0% were included in the study group. In 146 patients (32.22%), DR developed or progressed during the five-year follow-up. Baseline HbA1c level was the only independent risk factor for DR progression (p
