Clinical Infectious Diseases Advance Access published February 9, 2016
1 Applicability of HCV RNA viral load thresholds for 8-week treatments in patients with chronic hepatitis C genotype 1 infection
Johannes Vermehren1,*, Benjamin Maasoumy2,*, Raoel Maan3,4, Gavin Cloherty5,
cr ipt
Caterina Berkowski1, Jordan J. Feld3, Markus Cornberg2, Jean-Michel Pawlotsky6,7, Stefan Zeuzem1, Michael P. Manns2, Christoph Sarrazin1,†, Heiner Wedemeyer2,†
1
2
us
Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule
Hannover, Hannover, Germany 3
Toronto Centre for Liver Disease, Sandra Rotman Centre for Global Health, University of Toronto,
4
M an
Toronto, ON, Canada
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam,
Rotterdam, The Netherlands 5
Abbott Molecular, Des Plaines, IL, USA
6
National Reference Center for Viral Hepatitis B, C and D, Hopital Henri Mondor, Université Paris-Est,
Créteil, France 7
ed
INSERM U955, Créteil, France
pt
Corresponding author: Johannes Vermehren, MD, Medizinische Klinik 1, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main,
ce
Germany, Tel: +49-69-6301-5122, Fax: +49-69-6301-83112, Email: [email protected]
Ac
*J. V. and B. M. contributed equally to this work †
C. S. and H. W. contributed equally to this work
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail [email protected].
Downloaded from http://cid.oxfordjournals.org/ at The Chinese University of Hong Kong on February 27, 2016
Medizinische Klinik 1, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany
2 Alternate corresponding author: Benjamin Maasoumy, MD, Medizinische Hochschule Hannover, Klinik für Gastroenterologie, Hepatologie und Endokrinologie, CarlNeuberg-Str. 1, 30625 Hannover, Email: [email protected]
cr ipt
Summary
Determination of baseline HCV RNA thresholds for 8-week treatment regimens as
suggested by phase 3 trial data may not be reliably applied in clinical practice as the
us M an
Abstract
Background. Interferon-free treatment of chronic hepatitis C virus (HCV) genotype 1 infection may be shortened to 8 weeks in treatment-naïve, non-cirrhotic patients with baseline HCV RNA of
1 Applicability of HCV RNA viral load thresholds for 8-week treatments in patients with chronic hepatitis C genotype 1 infection
Johannes Vermehren1,*, Benjamin Maasoumy2,*, Raoel Maan3,4, Gavin Cloherty5,
cr ipt
Caterina Berkowski1, Jordan J. Feld3, Markus Cornberg2, Jean-Michel Pawlotsky6,7, Stefan Zeuzem1, Michael P. Manns2, Christoph Sarrazin1,†, Heiner Wedemeyer2,†
1
2
us
Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule
Hannover, Hannover, Germany 3
Toronto Centre for Liver Disease, Sandra Rotman Centre for Global Health, University of Toronto,
4
M an
Toronto, ON, Canada
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam,
Rotterdam, The Netherlands 5
Abbott Molecular, Des Plaines, IL, USA
6
National Reference Center for Viral Hepatitis B, C and D, Hopital Henri Mondor, Université Paris-Est,
Créteil, France 7
ed
INSERM U955, Créteil, France
pt
Corresponding author: Johannes Vermehren, MD, Medizinische Klinik 1, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main,
ce
Germany, Tel: +49-69-6301-5122, Fax: +49-69-6301-83112, Email: [email protected]
Ac
*J. V. and B. M. contributed equally to this work †
C. S. and H. W. contributed equally to this work
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail [email protected].
Downloaded from http://cid.oxfordjournals.org/ at The Chinese University of Hong Kong on February 27, 2016
Medizinische Klinik 1, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany
2 Alternate corresponding author: Benjamin Maasoumy, MD, Medizinische Hochschule Hannover, Klinik für Gastroenterologie, Hepatologie und Endokrinologie, CarlNeuberg-Str. 1, 30625 Hannover, Email: [email protected]
cr ipt
Summary
Determination of baseline HCV RNA thresholds for 8-week treatment regimens as
suggested by phase 3 trial data may not be reliably applied in clinical practice as the
us M an
Abstract
Background. Interferon-free treatment of chronic hepatitis C virus (HCV) genotype 1 infection may be shortened to 8 weeks in treatment-naïve, non-cirrhotic patients with baseline HCV RNA of
