Life Sciences, Vol . 21, pp . 901-906 Printed is the U .S .A .
Pergamon Press
Ci~PAM ~ DOPAMINC~rE2E[A'Im STE~]0't7~ED BIIiAVIOR Wih ;am J . Weines, Q~ristopher Goetz, Paul A. Nausieda, and Harold L. IClawans Department of Neurological Sciences 1a181'YPrE8t7jrteriaihSt . hL7ke 's Nlac7iral CeTItPr Chicago, Illinois 60612 (Received in final form August 15, 1977)
The effect of clanazepam an behaviar~al stereotypy induced by a number i+,a,;;~ agani,sts was investigated . C1~~~ inhibited of r lewc3opa- a:d a~ta°, ; *w-; *~ ~ behavior in guinea Pigs but dial not alter lergatrile- ar ate+*rr+ ; *,a-; n7+~3 stereotypy . The results suggest that c].onazepmn influences the central doPalninergic system through a direct effect of dopaninergic presynaptic mechanisns . Clanaz~n, a new benzodiaz~n derivative, has been recently introduced for the treatment of seizure di~ ~~ . The drug's aieoi~anie
Pergamon Press
Ci~PAM ~ DOPAMINC~rE2E[A'Im STE~]0't7~ED BIIiAVIOR Wih ;am J . Weines, Q~ristopher Goetz, Paul A. Nausieda, and Harold L. IClawans Department of Neurological Sciences 1a181'YPrE8t7jrteriaihSt . hL7ke 's Nlac7iral CeTItPr Chicago, Illinois 60612 (Received in final form August 15, 1977)
The effect of clanazepam an behaviar~al stereotypy induced by a number i+,a,;;~ agani,sts was investigated . C1~~~ inhibited of r lewc3opa- a:d a~ta°, ; *w-; *~ ~ behavior in guinea Pigs but dial not alter lergatrile- ar ate+*rr+ ; *,a-; n7+~3 stereotypy . The results suggest that c].onazepmn influences the central doPalninergic system through a direct effect of dopaninergic presynaptic mechanisns . Clanaz~n, a new benzodiaz~n derivative, has been recently introduced for the treatment of seizure di~ ~~ . The drug's aieoi~anie
