Clin Physiol Funct Imaging (2014) 34, pp405–409
doi: 10.1111/cpf.12120
SHORT COMMUNICATION
Poor agreement between transcranial Doppler and near-infrared spectroscopy-based estimates of cerebral blood flow changes in sepsis Linea N. Toksvang1, Ronni R. Plovsing2, Marie W. Petersen2, Kirsten Møller1,3 and Ronan M. G. Berg1,2 1
Centre of Inflammation and Metabolism, University Hospital Rigshospitalet, 2Intensive Care Unit 4131, University Hospital Rigshospitalet, and 3Neurointensive Care Unit 2093, Department of Neuroanaesthesiology, University Hospital Rigshospitalet, Copenhagen Ø, Denmark
Summary Correspondence Ronan M. G. Berg, Rigshospitalet, Centre of Inflammation and Metabolism (CIM), Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark E-mail: [email protected]
Accepted for publication Received 6 July 2013; accepted 25 November 2013
Key words Bland–Altman; cerebral haemodynamics; nearinfrared spectroscopy; noradrenaline; septic shock; severe sepsis; transcranial Doppler; vasopressor treatment
Background Continuous monitoring of cerebral blood flow (CBF) may be valuable in critically ill patients with sepsis. In this study, we compared spatially resolved near-infrared spectroscopy (NIRS) to transcranial Doppler ultrasound (TCD)derived estimates of noradrenaline-associated changes in CBF in such patients. Methods Mean arterial blood pressure (MAP) was elevated by increasing the noradrenaline infusion rate in eight mechanically ventilated, critically ill patients diagnosed with severe sepsis or septic shock. The associated changes in CBF were assessed by simultaneous ipsilateral NIRS (ScO2) and TCD (middle cerebral artery blood flow velocity, MCAv) measurements. Results A total of fifteen simultaneous NIRS- and TCD-derived assessments of noradrenaline-associated changes in CBF were obtained. MAP was increased from 74 (median; interquartile range (IQR), 71–90) to 100 (median; IQR, 93–115) mmHg (P
doi: 10.1111/cpf.12120
SHORT COMMUNICATION
Poor agreement between transcranial Doppler and near-infrared spectroscopy-based estimates of cerebral blood flow changes in sepsis Linea N. Toksvang1, Ronni R. Plovsing2, Marie W. Petersen2, Kirsten Møller1,3 and Ronan M. G. Berg1,2 1
Centre of Inflammation and Metabolism, University Hospital Rigshospitalet, 2Intensive Care Unit 4131, University Hospital Rigshospitalet, and 3Neurointensive Care Unit 2093, Department of Neuroanaesthesiology, University Hospital Rigshospitalet, Copenhagen Ø, Denmark
Summary Correspondence Ronan M. G. Berg, Rigshospitalet, Centre of Inflammation and Metabolism (CIM), Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark E-mail: [email protected]
Accepted for publication Received 6 July 2013; accepted 25 November 2013
Key words Bland–Altman; cerebral haemodynamics; nearinfrared spectroscopy; noradrenaline; septic shock; severe sepsis; transcranial Doppler; vasopressor treatment
Background Continuous monitoring of cerebral blood flow (CBF) may be valuable in critically ill patients with sepsis. In this study, we compared spatially resolved near-infrared spectroscopy (NIRS) to transcranial Doppler ultrasound (TCD)derived estimates of noradrenaline-associated changes in CBF in such patients. Methods Mean arterial blood pressure (MAP) was elevated by increasing the noradrenaline infusion rate in eight mechanically ventilated, critically ill patients diagnosed with severe sepsis or septic shock. The associated changes in CBF were assessed by simultaneous ipsilateral NIRS (ScO2) and TCD (middle cerebral artery blood flow velocity, MCAv) measurements. Results A total of fifteen simultaneous NIRS- and TCD-derived assessments of noradrenaline-associated changes in CBF were obtained. MAP was increased from 74 (median; interquartile range (IQR), 71–90) to 100 (median; IQR, 93–115) mmHg (P
