Scandinavian Journal of Clinical and Laboratory Investigation
ISSN: 0036-5513 (Print) 1502-7686 (Online) Journal homepage: http://www.tandfonline.com/loi/iclb20
Progression of Nephropathy in Long-Term Diabetics with Proteinuria and Effect of Initial AntiHypertensive Treatment C. E. Mogensen To cite this article: C. E. Mogensen (1976) Progression of Nephropathy in Long-Term Diabetics with Proteinuria and Effect of Initial Anti-Hypertensive Treatment, Scandinavian Journal of Clinical and Laboratory Investigation, 36:4, 383-388 To link to this article: http://dx.doi.org/10.1080/00365517609055274
Published online: 14 Feb 2011.
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Citing articles: 7 View citing articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=iclb20 Download by: [University of Sydney Library]
Date: 03 October 2015, At: 02:56
Scand. I . clin. Lab.
Invest.,
Vol. 36, 1976.
Progression of Nephropathy in Long-Term Diabetics with Proteinuria and Effect of Initial Anti-Hypertensive Treatment C. E. MOGENSEN Second University Clinic of Internal Medicine, Kommunehospitalet, Arhus, Denmark
Downloaded by [University of Sydney Library] at 02:56 03 October 2015
Mogensen, C. E. Progression of Nephropathy in Long-Term Diabetics with Proteinuria and Effect of Initial Anti-Hypertensive Treatment. Scand. J. clin. Lab Invest. 36, 383-388, 1976. The rate of progression of nephropathy was studied in 6 young male diabetics with intermittent proteinuria (AlbustixB) and in 10 young male diabetics with constant proteinuria by measuring g1omerula.r filtration rate (GFR), renal plasma flow (RPF), and urinary albumin excretion by exact techniques. Albumin excretion was elevated in both the recumbent and the erect position in patients with intermittent proteinuria. GFR and RPF were at the same level as in diabetics without proteinuria, and no deterioration in renal function was noted during a mean control period of 32 months. In the patients with constant proteinuria the fall rate during a mean period of 33.6 months for GFR and RPF was 0.91 ml/rnin/month~0.68(S.D.) and 4.38 ml/min/month +_ 3.23 (S.D.) respectively. Initial fall rate in GFR correlated well with long-term fall rate, both of which were studied in 7 patients. In the same patients there was a positive correlation between the fall rate in GFR and diastolic blood pressure as well as albumin clearance. In 8 patients with constant proteinuria and mean blood pressure of 1591101 mmHg, antihypertensive treatment was started with propranolol alone or combined with hydralazine and furosemide. During a treatment period of 47 days blood pressure was reduced to 143/93 mmHg, and in the same period urinary albumin excretion was reduced significantly from a mean value of 3547 pg/min to 2414 wg/min (P
ISSN: 0036-5513 (Print) 1502-7686 (Online) Journal homepage: http://www.tandfonline.com/loi/iclb20
Progression of Nephropathy in Long-Term Diabetics with Proteinuria and Effect of Initial AntiHypertensive Treatment C. E. Mogensen To cite this article: C. E. Mogensen (1976) Progression of Nephropathy in Long-Term Diabetics with Proteinuria and Effect of Initial Anti-Hypertensive Treatment, Scandinavian Journal of Clinical and Laboratory Investigation, 36:4, 383-388 To link to this article: http://dx.doi.org/10.1080/00365517609055274
Published online: 14 Feb 2011.
Submit your article to this journal
Article views: 28
View related articles
Citing articles: 7 View citing articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=iclb20 Download by: [University of Sydney Library]
Date: 03 October 2015, At: 02:56
Scand. I . clin. Lab.
Invest.,
Vol. 36, 1976.
Progression of Nephropathy in Long-Term Diabetics with Proteinuria and Effect of Initial Anti-Hypertensive Treatment C. E. MOGENSEN Second University Clinic of Internal Medicine, Kommunehospitalet, Arhus, Denmark
Downloaded by [University of Sydney Library] at 02:56 03 October 2015
Mogensen, C. E. Progression of Nephropathy in Long-Term Diabetics with Proteinuria and Effect of Initial Anti-Hypertensive Treatment. Scand. J. clin. Lab Invest. 36, 383-388, 1976. The rate of progression of nephropathy was studied in 6 young male diabetics with intermittent proteinuria (AlbustixB) and in 10 young male diabetics with constant proteinuria by measuring g1omerula.r filtration rate (GFR), renal plasma flow (RPF), and urinary albumin excretion by exact techniques. Albumin excretion was elevated in both the recumbent and the erect position in patients with intermittent proteinuria. GFR and RPF were at the same level as in diabetics without proteinuria, and no deterioration in renal function was noted during a mean control period of 32 months. In the patients with constant proteinuria the fall rate during a mean period of 33.6 months for GFR and RPF was 0.91 ml/rnin/month~0.68(S.D.) and 4.38 ml/min/month +_ 3.23 (S.D.) respectively. Initial fall rate in GFR correlated well with long-term fall rate, both of which were studied in 7 patients. In the same patients there was a positive correlation between the fall rate in GFR and diastolic blood pressure as well as albumin clearance. In 8 patients with constant proteinuria and mean blood pressure of 1591101 mmHg, antihypertensive treatment was started with propranolol alone or combined with hydralazine and furosemide. During a treatment period of 47 days blood pressure was reduced to 143/93 mmHg, and in the same period urinary albumin excretion was reduced significantly from a mean value of 3547 pg/min to 2414 wg/min (P
