HHS Public Access Author manuscript Author Manuscript
Arch Phys Med Rehabil. Author manuscript; available in PMC 2017 January 01. Published in final edited form as: Arch Phys Med Rehabil. 2016 January ; 97(1): 45–52. doi:10.1016/j.apmr.2015.08.423.
Sensorimotor Peripheral Nerve Function and the Longitudinal Relationship with Endurance Walking in the Health, Aging and Body Composition Study
Author Manuscript
Brittney S. Lange-Maia, PhD, MPHa, Anne B. Newman, MD, MPHa, Jane A. Cauley, DrPHa, Robert M. Boudreau, PhDa, John M. Jakicic, PhDb, Paolo Caserotti, PhDc, Nancy W. Glynn, PhDa, Tamara B. Harris, MD, MSd, Stephen B. Kritchevsky, PhDe, Ann V. Schwartz, PhD, MPHf, Suzanne Satterfield, MD, DrPHg, Eleanor M. Simonsick, PhDh, Aaron I. Vinik, MD, PhDI, Sasa Zivkovic, MDj, Elsa S. Strotmeyer, PhD, MPHa, and for the Health, Aging, and Body Composition Study aDepartment
of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
bDepartment
of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, PA cDepartment
of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark
dIntramural
Author Manuscript
Research Program, Laboratory of Epidemiology, and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD eDivision
of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC
fDepartment
of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA
gDepartment
of Preventive Medicine, University of Tennessee Health Science Center, Memphis,
TN hTranslational
Gerontology Branch, National Institute on Aging, National Institutes of Health,
Baltimore, MD iDepartment
of Neurobiology, Eastern Virginia Medical School, Norfolk, VA
Author Manuscript
jVeterans
Affairs Pittsburgh Health Care System and Department of Neurology, University of Pittsburgh, Pittsburgh, PA
Corresponding Author: Elsa S. Strotmeyer, PhD, MPH, University of Pittsburgh, Department of Epidemiology, 130 N. Bellefield Ave, Room 515, Pittsburgh, PA 15213, Fax: 412-383-1308, [email protected]. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Presented to the Gerontological Society of America, November 6, 2014, Washington, D.C. Disclosure: Dr. Vinik reports a financial relationship with Merck, ISIS Pharmaceuticals, and PamLab outside the submitted work. The other authors have nothing to disclose.
Lange-Maia et al.
Page 2
Abstract Author Manuscript
Objectives—To determine whether lower extremity sensorimotor peripheral nerve deficits are associated with reduced walking endurance in older adults. Design—Prospective cohort study with six years of follow-up. Setting—Two U.S. clinical sites in (Pittsburgh, PA and Memphis, TN). Participants—Community-dwelling older adults enrolled in Health, Aging and Body Composition study from the 2000/01 annual clinical examination (n=2393; age 76.5 ± 2.9 years; 48.2% male; 38.2% black) and subset with longitudinal data (n=1,178). Interventions—Not applicable
Author Manuscript
Main Outcome Measures—Participants underwent peripheral nerve function examination in 2000/01, including peroneal motor nerve conduction amplitude and velocity, vibration perception threshold, and monofilament testing. Symptoms of lower-extremity peripheral neuropathy included numbness or tingling and sudden stabbing, burning, pain, or aches in the feet or legs. The long distance corridor walk (LDCW; 400m) was administered in 2000/01 and every two years afterwards for 6 years to assess endurance walking performance over time. Results—In separate fully adjusted linear mixed models poor vibration threshold (>130 microns), 10-g and 1.4-g monofilament insensitivity were each associated with slower LDCW completion time (16.0, 14.1, and 6.7, seconds slower, respectively, P
Arch Phys Med Rehabil. Author manuscript; available in PMC 2017 January 01. Published in final edited form as: Arch Phys Med Rehabil. 2016 January ; 97(1): 45–52. doi:10.1016/j.apmr.2015.08.423.
Sensorimotor Peripheral Nerve Function and the Longitudinal Relationship with Endurance Walking in the Health, Aging and Body Composition Study
Author Manuscript
Brittney S. Lange-Maia, PhD, MPHa, Anne B. Newman, MD, MPHa, Jane A. Cauley, DrPHa, Robert M. Boudreau, PhDa, John M. Jakicic, PhDb, Paolo Caserotti, PhDc, Nancy W. Glynn, PhDa, Tamara B. Harris, MD, MSd, Stephen B. Kritchevsky, PhDe, Ann V. Schwartz, PhD, MPHf, Suzanne Satterfield, MD, DrPHg, Eleanor M. Simonsick, PhDh, Aaron I. Vinik, MD, PhDI, Sasa Zivkovic, MDj, Elsa S. Strotmeyer, PhD, MPHa, and for the Health, Aging, and Body Composition Study aDepartment
of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
bDepartment
of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, PA cDepartment
of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark
dIntramural
Author Manuscript
Research Program, Laboratory of Epidemiology, and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD eDivision
of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC
fDepartment
of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA
gDepartment
of Preventive Medicine, University of Tennessee Health Science Center, Memphis,
TN hTranslational
Gerontology Branch, National Institute on Aging, National Institutes of Health,
Baltimore, MD iDepartment
of Neurobiology, Eastern Virginia Medical School, Norfolk, VA
Author Manuscript
jVeterans
Affairs Pittsburgh Health Care System and Department of Neurology, University of Pittsburgh, Pittsburgh, PA
Corresponding Author: Elsa S. Strotmeyer, PhD, MPH, University of Pittsburgh, Department of Epidemiology, 130 N. Bellefield Ave, Room 515, Pittsburgh, PA 15213, Fax: 412-383-1308, [email protected]. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Presented to the Gerontological Society of America, November 6, 2014, Washington, D.C. Disclosure: Dr. Vinik reports a financial relationship with Merck, ISIS Pharmaceuticals, and PamLab outside the submitted work. The other authors have nothing to disclose.
Lange-Maia et al.
Page 2
Abstract Author Manuscript
Objectives—To determine whether lower extremity sensorimotor peripheral nerve deficits are associated with reduced walking endurance in older adults. Design—Prospective cohort study with six years of follow-up. Setting—Two U.S. clinical sites in (Pittsburgh, PA and Memphis, TN). Participants—Community-dwelling older adults enrolled in Health, Aging and Body Composition study from the 2000/01 annual clinical examination (n=2393; age 76.5 ± 2.9 years; 48.2% male; 38.2% black) and subset with longitudinal data (n=1,178). Interventions—Not applicable
Author Manuscript
Main Outcome Measures—Participants underwent peripheral nerve function examination in 2000/01, including peroneal motor nerve conduction amplitude and velocity, vibration perception threshold, and monofilament testing. Symptoms of lower-extremity peripheral neuropathy included numbness or tingling and sudden stabbing, burning, pain, or aches in the feet or legs. The long distance corridor walk (LDCW; 400m) was administered in 2000/01 and every two years afterwards for 6 years to assess endurance walking performance over time. Results—In separate fully adjusted linear mixed models poor vibration threshold (>130 microns), 10-g and 1.4-g monofilament insensitivity were each associated with slower LDCW completion time (16.0, 14.1, and 6.7, seconds slower, respectively, P
