case of Tetanus since I began the use of the Tartaric solution in 1872." " The Major Terpa Pinto* writes, vol. II., page 91, of quinine, and three grammes of caustics pulverized in three that medicament, which I introduced into the system at short intervals, calmed my feverish hypodermic injections10th (having injected on the 9th) I was state, so that on the able to rise, feeling considerably relieved." Other writers have given their favourable testimony on the safety of the hypodermic injection of quinine dissolved in Tartaric Acid. Fifteen minims of Mr. Scriven's solution contain five grains he was accustomed to inject of quinine, and which amount in the case of adults. Notwithstanding the caution of the authorities, does not Mr. Scriven's and others' experience fairly reopen the question ' his method and precautions. and justify further trials with on cholera, seeking to apply In 1871 I pulished an article of Jenncr to the preventhe method of the great discovery " but why need we consider tion of cholera, and asking Vaccination as the final and easiest method of prophylactic was apt to show in man, on the measures," now that cholera influences ; that it had occurrence of shock or depressing that it of great corelation with extremes but season-changes; rather an allied form of was not a specific existence, further that cholera ceased with the series of fevers. I saw in the case of ships, with certain changes of locality, and Hence arose my suggestion of certain changed latitudes. as prophylaxes to those injecting arsenic and quinine who were not affected. in Regiment, Jail or ship, to enter into a discussion of But my object now, is not to express a hope, that with ; but rather _

&orr?S}3onbence.

profound analogies the support of Mr. Scriven's experience, some medical trial to my suggestion. officer may approve and give Nor does it appear to me unreasonable, after the proved injection of quinine in fevers efficacy of the hypodermic in cases of actual cholera : to give the same method a trial to expect good from the method but my own studies led me as a

THE HYPODERMIC

INJECTION

prophylactic, rather

Yours

OF QUININE AS A

To the Editor of the Sir,?Between the years 1SG0 and

1870 I made eight coolie emigrants from charge in medical vova^es Calcutta to the West Indies, during which period I had resolved, should cholera appear on board, to hypodermically inject, with solution of Arsenic and Quinine, all those 7iof affected I will not ask space in 7?? journal, at present, to state the analogies on which I based my idea : I have on them in the medical many occasions press. But no epidemic of cholera showed in my voyages: I have therefore been unable to es my plan. Having however brought the pioposal under the notice of the medical authorities in India, 1 have been informed in reply "that owing to the danger attending the hypodermic injection of quinine in this climate (India), the practice has been prohibited." I do not for a moment doubt, that this prohibition has had, in the past, a good apparent cause : but on the other hand some most important testithe safety of this method, of mony lias been given as to

truly,

William H. Pearse, M. D., Ediit.,

PROPHYLACTIC AGAINST CHOLERA. Tndiah Medical Gazette.

than in the actual disease.

May 12th,,

1882.

Plymouth Public

Senior Physician, Dispensary, Plymouth,

of

published

administering quinine.

Mr. J.B. Scriven, late Civil burgeon of Lahore, m the Lancet of April 29th, gives a formula of one drachm of Sulphate of Quinine, half a drachm of Tartaric acid, distilled water to three drachms. He further describes his syringe, which has its orifice on the side of the stem, about one-sixtli of an inch from the point. Mr. Scriven, again in the Lancet of December 31st, 1881, " I have used it in a great number writes of his practice ; of cases since 1870, being careful to carry out my own proposal for the avoidance of abscess and ulceration, viz., to introduce the nozzle of the syringe so that the aperture by which the quinine escapes into the cellular tissue, shall be turned away from the skin. The result has beeni that I have not had a single case of abscess, ulceration, sloughing, or evil of any hind, save a temporary inflammation o? the arm requiring rest and cold lotions, I have had no

1876,'

*

?

JIow

I crossed Jfricct," 1SS1 London