Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. D M Mancini, H Eisen, W Kussmaul, R Mull, L H Edmunds, Jr and J R Wilson Circulation. 1991;83:778-786 doi: 10.1161/01.CIR.83.3.778 Circulation is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Copyright © 1991 American Heart Association, Inc. All rights reserved. Print ISSN: 0009-7322. Online ISSN: 1524-4539
The online version of this article, along with updated information and services, is located on the World Wide Web at: http://circ.ahajournals.org/content/83/3/778
Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Circulation can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at: http://www.lww.com/reprints Subscriptions: Information about subscribing to Circulation is online at: http://circ.ahajournals.org//subscriptions/
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Value of Peak Exercise Oxygen Consumption for Optimal Timing of Cardiac Transplantation in Ambulatory Patients With Heart Failure Donna M. Mancini, MD; Howard Eisen, MD; William Kussmaul, MD; Rebekah Mull, RN; L. Henry Edmunds Jr., MD; and John R. Wilson, MD
Background. Optimal timing of cardiac transplantation in ambulatory patients with severe left ventricular dysfunction is often difficult. To determine whether measurement of peak oxygen consumption (Vo2) during maximal exercise testing can be used to identify patients in whom transplantation can be safely deferred, we prospectively performed exercise testing on all ambulatory patients referred for transplant between October 1986 and December 1989. Methods and Results. Patients were assigned into one of three groups on the basis of exercise data: Group 1 (n=35) comprised patients accepted for transplant (Vo214 ml/kg/min); and group 3 (n=27) comprised patients with low Vo2 rejected for transplant due to noncardiac problems. All three groups were comparable in New York Heart Association functional class, ejection fraction, and cardiac index (p=NS). Pulmonary capillary wedge pressure was significantly lower in group 2 than in either group 1 or 3 (p
The online version of this article, along with updated information and services, is located on the World Wide Web at: http://circ.ahajournals.org/content/83/3/778
Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Circulation can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at: http://www.lww.com/reprints Subscriptions: Information about subscribing to Circulation is online at: http://circ.ahajournals.org//subscriptions/
Downloaded from http://circ.ahajournals.org/ at OREGON STATE UNIVERSITY on June 13, 2014
778
Value of Peak Exercise Oxygen Consumption for Optimal Timing of Cardiac Transplantation in Ambulatory Patients With Heart Failure Donna M. Mancini, MD; Howard Eisen, MD; William Kussmaul, MD; Rebekah Mull, RN; L. Henry Edmunds Jr., MD; and John R. Wilson, MD
Background. Optimal timing of cardiac transplantation in ambulatory patients with severe left ventricular dysfunction is often difficult. To determine whether measurement of peak oxygen consumption (Vo2) during maximal exercise testing can be used to identify patients in whom transplantation can be safely deferred, we prospectively performed exercise testing on all ambulatory patients referred for transplant between October 1986 and December 1989. Methods and Results. Patients were assigned into one of three groups on the basis of exercise data: Group 1 (n=35) comprised patients accepted for transplant (Vo214 ml/kg/min); and group 3 (n=27) comprised patients with low Vo2 rejected for transplant due to noncardiac problems. All three groups were comparable in New York Heart Association functional class, ejection fraction, and cardiac index (p=NS). Pulmonary capillary wedge pressure was significantly lower in group 2 than in either group 1 or 3 (p
