META-ANALYSIS e-ISSN 1643-3750 © Med Sci Monit, 2015; 21: 921-928 DOI: 10.12659/MSM.892276

Epidural Analgesia with Amide Local Anesthetics, Bupivacaine, and Ropivacaine in Combination with Fentanyl for Labor Pain Relief: A Meta-Analysis

Received: 2014.08.19 Accepted: 2014.10.24 Published: 2015.03.29

Authors’ Contribution: Study Design  A Data Collection  B Analysis  C Statistical Data Interpretation  D Manuscript Preparation  E Literature Search  F Funds Collection  G

AB 1 CD 2 BE 1 D 3 A 4



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Yiyang Li Cong Hu Yanyan Fan Huixia Wang Hongmei Xu

1 Department of Gynecology, First Hospital of Jilin University, Changchun, Jilin, China 2 Center of Reproductive Medicine, First Hospital of Jilin University, Changchun, Jilin, China 3 Department of Anesthesiology, Jinan General Hospital, PLA Jinan Military Area Command, Jinan, Shandong, China 4 Department of Obstetrics, First Hospital of Jilin University, Changchun, Jilin, China

Hongmei Xu, e-mail: [email protected] Departmental sources

The study compares the effectiveness of bupivacaine and fentanyl (BUPI-FEN) and ropivacaine and fentanyl (ROPI-EFN) in epidural analgesia for labor pain through a meta-analysis of relevant randomized clinical trials. Multiple electronic databases were searched using appropriate MeSH terms and keywords for original English language research papers published between 1990 and March 2014. Meta-analyses results were based on the mean differences between the groups as well as odds ratios where appropriate. Statistical heterogeneity amongst the included studies was tested by I2 index. Nine studies that met the inclusion criteria were selected for analysis which consisted of 556 parturient patients. The duration of the second stage of labor was significantly shorter in the BUPI-FEN group by a mean of –6.87 (–10.98, –2.77; P

Epidural analgesia with amide local anesthetics, bupivacaine, and ropivacaine in combination with fentanyl for labor pain relief: a meta-analysis.

The study compares the effectiveness of bupivacaine and fentanyl (BUPI-FEN) and ropivacaine and fentanyl (ROPI-EFN) in epidural analgesia for labor pa...
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