G Model IJP 14914 No. of Pages 1
International Journal of Pharmaceutics xxx (2015) xxx
Contents lists available at ScienceDirect
International Journal of Pharmaceutics journal homepage: www.elsevier.com/locate/ijpharm
Editorial
Foreword: SI printing pharmaceuticals
“The science of pharmaceutics has a long tradition of embracing and developing new technologies, in order to develop and manufacture better performing medicines and to optimise drug delivery profiles. Ink-jet and 3D printing, developed as tools for image reproduction and rapid prototyping respectively, provide the latest examples of technologies being exploited by pharmaceutical scientists. While printing technologies have attracted widespread media interest in many areas of medicine (for instance, printing of organs and other applications in regenerative medicine), they also have many applications in pharmaceutical development and manufacture. This Special Issue showcases recent work by experts in the field, demonstrating a broad range of novel uses of printing pharmaceuticals and is designed to inspire others to explore and develop the highlighted technologies. The papers explore many applications of printing technology and consider printing of both solutions and solids. Starting with ink-jet printing, we have papers looking at printing anticancer drugs onto microneedles, fabricating medicated oral wafers with flexographic printing, taste-masking oral films and a comparison of printed oral films versus casted oral films. We also have a number of review articles, considering factors affecting ink-jet printing for dispensing, its potential for research and manufacturing, the roles that ink-jet printing may play in formulation of oral wafers and its potential for biomolecule and cell-based applications. Moving to solids and semisolids, we have papers looking at the use of 3D printing to fabricate modified and controlled release tablets, considering applications such as manufacture of multicompartment tablets and tablets with geometries not achievable via powder compaction. We also have a review of rheological methods for characterising melt processability of polymer
extrudates. Finally, there is a demonstration of the use of 3D printing for manufacture of devices to help medical research, in this case to prepare brain slices for imaging. We would like to express our thanks to all the authors who have contributed such fantastic articles to this issue. We also thank Prof Sandy Florence for suggesting a Special Issue on Printing Pharmaceuticals would be both timely and relevant, and Prof Abdul Basit and Dr Alvaro Goyanes with whom we develop our own printing capabilities. There is little doubt that printing technology has the potential to revolutionise pharmaceutical design, manufacture and delivery over the coming decades and we hope that the topics discussed here inspire further development of this exciting field”. A. Buanz S. Gaisford FRSC CCHem SRPharmS* S. Hilton Reader and Head of Research Dept. of Pharmaceutics, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, United Kingdom * Corresponding author. Tel.: +44 0 207 753 5863 fax: +44 0 207 753 5942. E-mail addresses: [email protected], http://iris.ucl.ac.uk/iris/browse/profile?upi=SGAIS8 (S. Gaisford). Received 14 May 2015 Accepted 14 May 2015 Available online xxx
http://dx.doi.org/10.1016/j.ijpharm.2015.05.044 0378-5173/ ã 2015 Elsevier B.V. All rights reserved.
Please cite this article in press as: A. Buanz, et al., Foreword: SI printing pharmaceuticals, Int J Pharmaceut (2015), http://dx.doi.org/10.1016/j. ijpharm.2015.05.044
International Journal of Pharmaceutics xxx (2015) xxx
Contents lists available at ScienceDirect
International Journal of Pharmaceutics journal homepage: www.elsevier.com/locate/ijpharm
Editorial
Foreword: SI printing pharmaceuticals
“The science of pharmaceutics has a long tradition of embracing and developing new technologies, in order to develop and manufacture better performing medicines and to optimise drug delivery profiles. Ink-jet and 3D printing, developed as tools for image reproduction and rapid prototyping respectively, provide the latest examples of technologies being exploited by pharmaceutical scientists. While printing technologies have attracted widespread media interest in many areas of medicine (for instance, printing of organs and other applications in regenerative medicine), they also have many applications in pharmaceutical development and manufacture. This Special Issue showcases recent work by experts in the field, demonstrating a broad range of novel uses of printing pharmaceuticals and is designed to inspire others to explore and develop the highlighted technologies. The papers explore many applications of printing technology and consider printing of both solutions and solids. Starting with ink-jet printing, we have papers looking at printing anticancer drugs onto microneedles, fabricating medicated oral wafers with flexographic printing, taste-masking oral films and a comparison of printed oral films versus casted oral films. We also have a number of review articles, considering factors affecting ink-jet printing for dispensing, its potential for research and manufacturing, the roles that ink-jet printing may play in formulation of oral wafers and its potential for biomolecule and cell-based applications. Moving to solids and semisolids, we have papers looking at the use of 3D printing to fabricate modified and controlled release tablets, considering applications such as manufacture of multicompartment tablets and tablets with geometries not achievable via powder compaction. We also have a review of rheological methods for characterising melt processability of polymer
extrudates. Finally, there is a demonstration of the use of 3D printing for manufacture of devices to help medical research, in this case to prepare brain slices for imaging. We would like to express our thanks to all the authors who have contributed such fantastic articles to this issue. We also thank Prof Sandy Florence for suggesting a Special Issue on Printing Pharmaceuticals would be both timely and relevant, and Prof Abdul Basit and Dr Alvaro Goyanes with whom we develop our own printing capabilities. There is little doubt that printing technology has the potential to revolutionise pharmaceutical design, manufacture and delivery over the coming decades and we hope that the topics discussed here inspire further development of this exciting field”. A. Buanz S. Gaisford FRSC CCHem SRPharmS* S. Hilton Reader and Head of Research Dept. of Pharmaceutics, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, United Kingdom * Corresponding author. Tel.: +44 0 207 753 5863 fax: +44 0 207 753 5942. E-mail addresses: [email protected], http://iris.ucl.ac.uk/iris/browse/profile?upi=SGAIS8 (S. Gaisford). Received 14 May 2015 Accepted 14 May 2015 Available online xxx
http://dx.doi.org/10.1016/j.ijpharm.2015.05.044 0378-5173/ ã 2015 Elsevier B.V. All rights reserved.
Please cite this article in press as: A. Buanz, et al., Foreword: SI printing pharmaceuticals, Int J Pharmaceut (2015), http://dx.doi.org/10.1016/j. ijpharm.2015.05.044
