Ramakrishna D, Pragna R Rao
Nanoparrticles: Is toxicity a concern??
NANOPARTICLES: IS TOXICITY A CONCEERN? Ramakrishnaa D1, Pragna R Rao2 1
Departmentt of Biochemisstry, Kaminen ni Institute of M Medical Scien nces, Sreepura am, Narketpallly, Nalgonda‐‐508 254.
2
Departmentt of Biochemisstry, Kasturba a Medical Colleege, Manipal,, Karnataka.
Correspondin ng author’s a address Dr. Ramakrisshna Devaki Associate Pro ofessor Department of Biochemisttry dical Sciences Kamineni Insstitute of Med Sreepuram Narketpally‐5508 254 Nalgonda Dt., A.P, India. Mobile: +91 9989561671 2829 Tel: +91 86822 272344, 272 Fax: +91 86882 272020 msmedicalcollege.org Email: ramakkrishna.d@kim Website: http://www.men ndeley.com/p profiles/ramakkrishna‐devakki
ABSTRACTT Nanotechnology involvingg manipulatio on of atoms and molecule es at the nan noscale is onee of the fron ntier areas off research in m modern science. During the last few yeaars, nanotech hnology has w witnessed breaakthroughs in n the fields off medicine, en nvironment, therapeutics, drug developpment and bio otechnology. This is due too the unique properties off nanomateriaals (e.g. chem mical, mecha anical, opticaal, magnetic, and biological) which m make them desirable forr commercial aand medical aapplications. C Considering thhe theory and d practice of u using nanoparrticles, nanote echnology hass a great poteential in impro oving treatme ent of variouss disorders and in vitro diagnostics. Hoowever, there e is not much h information available on the toxicity of o nanoparticlles in relation n to human health. Toxic eeffect of nano omaterials on n humans is th he primary co oncern of the e health indu stry. Nanomaaterials are able to cross bbiological membranes and d access cells, tissues and organs that larger‐sized partticles normallyy cannot. Nan nomaterials caan gain accesss to the blood d stream via in nhalation or in ngestion. This may lead to bboth genotoxicity and biochemical toxiciity. In this revview we try to o show which types, sizes aand concentra ations of nanooparticles are e safe for hum man use and tthis will help in developingg diagnostic, p prognostic and d therapeutic models using nanoparticles.
INTRODUCCTION Nanotechnology can be defined as the techniques a imed at charaacterizing and d producing m materials on th he nanometerr scale (
Nanoparrticles: Is toxicity a concern??
NANOPARTICLES: IS TOXICITY A CONCEERN? Ramakrishnaa D1, Pragna R Rao2 1
Departmentt of Biochemisstry, Kaminen ni Institute of M Medical Scien nces, Sreepura am, Narketpallly, Nalgonda‐‐508 254.
2
Departmentt of Biochemisstry, Kasturba a Medical Colleege, Manipal,, Karnataka.
Correspondin ng author’s a address Dr. Ramakrisshna Devaki Associate Pro ofessor Department of Biochemisttry dical Sciences Kamineni Insstitute of Med Sreepuram Narketpally‐5508 254 Nalgonda Dt., A.P, India. Mobile: +91 9989561671 2829 Tel: +91 86822 272344, 272 Fax: +91 86882 272020 msmedicalcollege.org Email: ramakkrishna.d@kim Website: http://www.men ndeley.com/p profiles/ramakkrishna‐devakki
ABSTRACTT Nanotechnology involvingg manipulatio on of atoms and molecule es at the nan noscale is onee of the fron ntier areas off research in m modern science. During the last few yeaars, nanotech hnology has w witnessed breaakthroughs in n the fields off medicine, en nvironment, therapeutics, drug developpment and bio otechnology. This is due too the unique properties off nanomateriaals (e.g. chem mical, mecha anical, opticaal, magnetic, and biological) which m make them desirable forr commercial aand medical aapplications. C Considering thhe theory and d practice of u using nanoparrticles, nanote echnology hass a great poteential in impro oving treatme ent of variouss disorders and in vitro diagnostics. Hoowever, there e is not much h information available on the toxicity of o nanoparticlles in relation n to human health. Toxic eeffect of nano omaterials on n humans is th he primary co oncern of the e health indu stry. Nanomaaterials are able to cross bbiological membranes and d access cells, tissues and organs that larger‐sized partticles normallyy cannot. Nan nomaterials caan gain accesss to the blood d stream via in nhalation or in ngestion. This may lead to bboth genotoxicity and biochemical toxiciity. In this revview we try to o show which types, sizes aand concentra ations of nanooparticles are e safe for hum man use and tthis will help in developingg diagnostic, p prognostic and d therapeutic models using nanoparticles.
INTRODUCCTION Nanotechnology can be defined as the techniques a imed at charaacterizing and d producing m materials on th he nanometerr scale (
